Results 131 to 140 of about 28,511,988 (353)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Kaleidoscopic Data Science

Harvard Data Science Review, 2022
David C. Parkes
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

The case for data science in experimental chemistry: examples and recommendations

Nature Reviews Chemistry, 2022
J. Yano, K. Gaffney, J. Gregoire, Linda Hung, Abbas Ourmazd, Joshua Schrier, J. Sethian, F. Toma   +7 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Insightful Data Science

Harvard Data Science Review, 2021
Hongyu Zhao
doaj   +1 more source

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Nature Biotechnology, 2019
Evan Bolyen, J. Rideout, Matthew R. Dillon, Nicholas A. Bokulich, C. Abnet, Gabriel A. Al-Ghalith, Harriet Alexander, E. Alm, Manimozhiyan Arumugam, F. Asnicar, Yang Bai, J. Bisanz, K. Bittinger, A. Brejnrod, Colin J. Brislawn, C. T. Brown, B. Callahan, A. Caraballo-Rodríguez, John H. Chase, Emily K. Cope, R. D. da Silva, C. Diener, P. Dorrestein, G. Douglas, D. Durall, C. Duvallet, C. Edwardson, Madeleine Ernst, M. Estaki, Jennifer T. Fouquier, J. Gauglitz, S. Gibbons, D. Gibson, Antonio Gonzalez, Kestrel Gorlick, Jiarong Guo, Benjamin M Hillmann, S. Holmes, H. Holste, C. Huttenhower, G. Huttley, Stefan Janssen, Alan K. Jarmusch, Lingjing Jiang, Benjamin D. Kaehler, K. Kang, Christopher R. Keefe, P. Keim, S. Kelley, D. Knights, I. Koester, T. Kosciólek, Jorden Kreps, M. Langille, Joslynn S. Lee, R. Ley, Yong-xin Liu, E. Loftfield, C. Lozupone, Massoud Maher, C. Marotz, Bryan D. Martin, Daniel McDonald, L. McIver, A. Melnik, J. Metcalf, S. C. Morgan, James T. Morton, Ahmad Turan Naimey, Jose A Navas-Molina, Louis-Félix Nothias, Stephanie B. Orchanian, Talima R. Pearson, Samuel L. Peoples, D. Petráš, M. Preuss, E. Pruesse, Lasse Buur Rasmussen, A. Rivers, M. Robeson, P. Rosenthal, N. Segata, Michael Shaffer, A. Shiffer, R. Sinha, Se Jin Song, J. Spear, Austin D. Swafford, Luke R. Thompson, P. Torres, Pauline Trinh, A. Tripathi, P. Turnbaugh, Sabah Ul-Hasan, J. V. D. van der Hooft, Fernando Vargas, Y. Vázquez-Baeza, E. Vogtmann, Max von Hippel, William Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C. Weber, C. H. Williamson, A. Willis, Z. Xu, Jesse R. Zaneveld, Yilong Zhang, Qiyun Zhu, R. Knight, J. Caporaso   +111 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source