Results 131 to 140 of about 13,470,212 (338)

Insightful Data Science

open access: yesHarvard Data Science Review, 2021
Hongyu Zhao
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Accessing Earth science data from the EOS data and information system [PDF]

open access: yes
An overview of the Earth Observing System Data and Information System (EOSDIS) is presented, concentrating on the users' interactions with the system and highlighting those features that are driven by the unique requirements of the Global Change Research
Calvo, Sherri, Mcdonald, Kenneth R.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Data Science in Olfaction

open access: yes
AbstractAdvances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they are sensed and analyzed in the olfactory system from the nose to the brain. Drawing distinctions to color
Agarwal, Vivek   +3 more
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Phishing URL detection with neural networks: an empirical study

open access: yesScientific Reports
Cybercriminals create phishing websites that mimic legitimate websites to get sensitive information from companies, individuals, or governments. Therefore, using state-of-the-art artificial intelligence and machine learning technologies to correctly ...
Hayk Ghalechyan   +4 more
doaj   +1 more source

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