Results 161 to 170 of about 12,937,092 (315)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Responsible Data Science [PDF]

open access: yesBusiness & Information Systems Engineering, 2017
Aalst, Wil M. P. van der   +2 more
openaire   +2 more sources

Data Science at the Singularity

open access: yesHarvard Data Science Review
A purported `AI Singularity' has been in the public eye recently. Mass media and US national political attention focused on `AI Doom' narratives hawked by social media influencers. The European Commission is announcing initiatives to forestall `AI Extinction'.
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Toward construction of “data science” course group and “introduction to data science” course

open access: yes大数据, 2018
To adapt to data science and big data talent cultivation requirements of the new era,School of Information,Renmin University of China has reformed its course system in recent years.Three course groups as problem solving,computer system,and data science ...
Xiongpai QIN   +6 more
doaj  

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

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