Results 101 to 110 of about 24,469,419 (259)
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingBuilding type information indicates the functional properties of buildings and plays a crucial role in smart city development and urban socioeconomic activities.
Shaofeng Zhang +4 more
doaj +1 more source
Storing and Indexing Spatial Data in P2P Systems
, 2009 The peer-to-peer (P2P) paradigm has become very popular for storing and sharing information in a totally decentralized manner. At first, research focused on P2P systems that host 1D data. Nowadays, the need for P2P applications with multidimensional data
Skiadopoulos, S +5 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Selecting, Packaging, and Granting Access for Sharing Study Data
, 2017 Data in medical studies and research projects are captured, curated and analyzed, often, with a substantial personal and financial effort. Such study data are typically managed by institutions and groups who are involved in these studies and projects ...
Löffler, Markus +4 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
International Journal of Digital EarthLong time series and accurate subsurface temperature data in the global ocean are essential for ocean warming and climate change studies. The sparse in situ observations in the pre-Argo era hinder the reconstruction of long-time series observational data
An Wang, Hua Su
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source