Results 71 to 80 of about 956,345 (261)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Health Assessment of Terrestrial Ecosystems in China Based on the Adaptive Indicator Reduction Method

Remote Sensing
Assessing terrestrial ecosystem health in China is crucial for guiding national economic strategies and ecological conservation. To address the lack of a unified national evaluation system, this study integrates the Pressure–State–Response (PSR) and ...
Xiaoqin Wang, Dongyue Wang, Jianhui Chen, Mengjing Lin   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Building Type Classification Using CNN-Transformer Cross-Encoder Adaptive Learning From Very High Resolution Satellite Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Building type information indicates the functional properties of buildings and plays a crucial role in smart city development and urban socioeconomic activities.
Shaofeng Zhang, Mengmeng Li, Wufan Zhao, Xiaoqin Wang, Qunyong Wu   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Data Sharing [PDF]

European Heart Journal, 2017
Alfonso, Fernando, Adamyan, Karlen, Artigou, Jean-Yves, Aschermann, Michael, Boehm, Michael, Buendia, Alfonso, Chu, Pao-Hsien, Cohen, Ariel, dei Cas, Livio, Dilic, Mirza, Doubell, Anton, Echeverri, Dario, Enç, Nuray, Ferreira-González, Ignacio, Filipiak, Krzysztof J., Flammer, Andreas, Fleck, Eckart, Gatzov, Plamen, Ginghina, Carmen, Goncalves, Lino, Haouala, Habib, Hassanein, Mahmoud, Heusch, Gerd, Huber, Kurt, Hulín, Ivan, Ivanusa, Mario, Krittayaphong, Rungroj, Lau, Chu-Pak, Marinskis, Germanas, Mach, François, Felipe Moreira, Luiz, Nieminen, Tuomo, Oukerraj, Latifa, Perings, Stefan, Pierard, Luc, Potpara, Tatjana, Reyes-Caorsi, Walter, Rim, Se-Joong, Rødevand, Olaf, Saade, Georges, Sander, Mikael, Shlyakhto, Evgeny, Timuralp, Bilgin, Tousoulis, Dimitris, Ural, Dilek, Piek, J. J., Varga, Albert, Lüscher, Thomas F.   +47 more
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source