Results 61 to 70 of about 2,336,702 (258)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

On the convex layers of a planer dynamic set of points

open access: yesCeylon Journal of Science, 2018
The convex hull of a planer set of points can be defined as the set of vertices of the smallest convex polygon containing all the points. If S is a planer set of points then convex layers of S can be derived by iteratively computing the convex hull of S ...
K. R. Wijeweera, S. R. Kodituwakku
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Predicting the impact of public events and mobility in Smart Cities

open access: yesIET Smart Cities
The ubiquitous presence of smartphones and the ever‐expanding Internet of Things are generating a treasure trove of data on human movement. We harness the power of Artificial Intelligence to extract knowledge within this data, in particular for ...
Elena Bellodi   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Advancing smart tourism destinations: A case study using bidirectional encoder representations from transformers‐based occupancy predictions in torrevieja (Spain)

open access: yesIET Smart Cities
Tourism represents a crucial socio‐economic pillar globally, yet the multifaceted challenges it poses necessitate innovative management approaches. The paradigm of smart tourism harnesses advanced data analytics tools to promote both profitability and ...
José Ginés Giménez Manuel   +5 more
doaj   +1 more source

Optimizing Linked List-based Smart Contract on Ethereum with IPFS for E-book Management System

open access: yesJOIV: International Journal on Informatics Visualization
People are now widely adopting digital assets in various applications, integrating them into almost every aspect of their lives. Electronic books, or e-books, are one of the digital assets that result from the transformation of physical reading material ...
Maznun Arifa Mohammadan Makhtar   +4 more
doaj   +1 more source

THE STUDY OF THE INFLUENCE OF ASYMMETRY ON THE COMPLEXITY OF SOLVING THE TRAVELING SALESMAN PROBLEM BY THE BRANCH AND BOUND METHOD

open access: yesСовременные информационные технологии и IT-образование, 2019
The traveling salesman problem is the one of the most famous combinatorial optimization problems. This problem is important and at the same time difficult to solve, due to the exponential complexity of the exact methods of solution.
Nikolay V. Mamonov
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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