Results 91 to 100 of about 2,416,152 (243)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Uma discussão de oposições binárias nos Functional Requirements for Subject Authority Data (FRSAD)
Perspectivas em Ciência da InformaçãoRESUMO Como são poucos os estudos brasileiros que assumem declaradamente seus posicionamentos sobre as biases, este artigo propõe-se a apresentar uma discussão crítica sobre as biases na representação de assunto a partir dos Functional Requirements for ...
Suellen Oliveira Milani
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Tackling inter-subject variability in smartwatch data using factorization models
Scientific ReportsSmartwatches enable longitudinal and continuous data acquisition. This has the potential to remotely monitor (changes) of the health of users. However, differences among subjects (inter-subject variability) limit a model to generalize to unseen subjects.
Arman Naseri +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A multiple imputation-based sensitivity analysis approach for data subject to missing not at random. [PDF]
Stat Med, 2020 Hsu CH, He Y, Hu C, Zhou W.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Multiple Optima in Identification of ARX Models Subject to Missing Data
EURASIP Journal on Advances in Signal Processing, 2002 Special system identification algorithms are required if there are significant amounts of data missing. Some such algorithms have been developed previously and typically result in iterative procedures for the parameter estimation. Since missing data can
Wallin Ragnar, Isaksson Alf J
doaj +1 more source
An extended proportional hazards model for interval-censored data subject to instantaneous failures. [PDF]
Lifetime Data Anal, 2020 Withana Gamage PW +4 more
europepmc +1 more source