Results 111 to 120 of about 2,416,152 (243)

StratLearn-z: Improved photo-$z$ estimation from spectroscopic data subject to selection effects

open access: yesThe Open Journal of Astrophysics
A precise measurement of photometric redshifts (photo-z) is crucial for the success of modern photometric galaxy surveys. Machine learning (ML) methods show great promise in this context, but suffer from covariate shift in training sets due to selection ...
Chiara Moretti   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Semiparametric Model for Bivariate Survival Data Subject to Biased Sampling. [PDF]

open access: yesJ R Stat Soc Series B Stat Methodol, 2019
Piao J, Ning J, Shen Y.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Multilingual Subject Retrieval: Bibliotheca Alexandrina’s Subject Authority File and Linked Subject Data

open access: yes, 2015
The Bibliotheca Alexandrina (BA) has been developing its own authority file since September 2006. The file includes subject headings, personal names, corporate bodies, series, and uniform titles. The BA authority file is unique in that it is constructed on the actual collection and it establishes subject headings in the language of the item described ...
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The Use of Multiple Imputation for Data Subject to Limits of Detection. [PDF]

open access: yesSri Lankan J Appl Stat, 2014
Harel O, Perkins N, Schisterman EF.
europepmc   +1 more source

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