Results 101 to 110 of about 2,604,170 (298)

Database and Modern Database Technology

open access: yesInternational Research Journal on Advanced Engineering and Management (IRJAEM)
This paper articulates a holistic approach to study the future of database development as well as the interaction between AI and modern database technologies. Overall architecture is data-centric so that quality of data, security, and governance are enhanced. It addresses the scalability and cost-effectiveness of cloud-native versus serverless database
null Mr. Godly C Mathew Zachariah   +4 more
openaire   +1 more source

Freely available mean daily discharge series from Czechia: what can be inferred from them?

open access: yesE3S Web of Conferences, 2017
Most hydrometeorological data from Czechia are still provided for a fee. This especially applies to time series with a finer step than monthly. The fact that the data must be paid with respect to an expert’s appraisement and that the proper licence ...
Ledvinka Ondrej
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

WebCSD: the online portal to the Cambridge Structural Database [PDF]

open access: hybrid, 2010
Ian Thomas   +5 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Spatial selection of sparse pivots for similarity search in metric spaces

open access: yesJournal of Computer Science and Technology, 2007
Similarity search is a fundamental operation for applications that deal with unstructured data sources. In this paper we propose a new pivot-based method for similarity search, called Sparse Spatial Selection (SSS). The main characteristic of this method
Nieves Rodríguez Brisaboa   +3 more
doaj  

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