Results 101 to 110 of about 2,641,789 (298)
Priority channel selection based on detection history database [PDF]
, 2010 Johanna Vartiainen +3 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Spatial selection of sparse pivots for similarity search in metric spaces
Journal of Computer Science and Technology, 2007 Similarity search is a fundamental operation for applications that deal with unstructured data sources. In this paper we propose a new pivot-based method for similarity search, called Sparse Spatial Selection (SSS). The main characteristic of this method
Nieves Rodríguez Brisaboa +3 more
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
SCOPE: a probabilistic model for scoring tandem mass spectra against a peptide database [PDF]
, 2001 Vineet Bafna, Nathan Edwards
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
BMC Infectious DiseasesBackground Clostridioides difficile infections (CDIs) and recurrences (rCDIs) remain a major public health challenge due to substantial mortality and associated costs.
Ana Antunes +6 more
doaj +1 more source