Results 71 to 80 of about 4,269,596 (312)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Co-creation methods for public health research — characteristics, benefits, and challenges: a Health CASCADE scoping review

BMC Medical Research Methodology
Co-creation engages diverse stakeholders, including marginalized populations, in collaborative problem-solving to enhance engagement and develop contextually appropriate solutions.
D. Agnello, Vinayak Anand-Kumar, Q. An, J. de Boer, L. Delfmann, G. R. Longworth, Q. Loisel, Lauren McCaffrey, A. Steiner, S. Chastin   +9 more
semanticscholar   +1 more source

Organic farms in the Czech Republic – Map Portal presentation opportunities [PDF]

, 2011
The paper is aimed at presenting the map portal of organic farms in the Czech Republic. The pilot project is concerned with the South Bohemia Region.
Brozova, Ivana, Cervenkova, Eva, Jarolimek, Jan, Simek, Pavel, Vanek, Jiri, Vogeltanzova, Tereza   +5 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Knowledge database creation for design of polymer matrix composite

Computational materials science, 2022
Han-Sheng Huang, S. Mojumder, D. Suarez, Abdullah A. Amin, M. Fleming, Wing Kam Liu   +5 more
semanticscholar   +1 more source

Job creation and job destruction in Estonia: labour reallocation and structural changes [PDF]

, 2004
This paper documents and analyses gross job flows and their determinants in Estonia over the years 1995-2001, using a unique database from the Estonian Business Registry.
Eamets, R., Masso, J., Philips, K.
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Database Creation and Dialect-Wise Comparative Analysis of Prosodic Features for Punjabi Language

Journal of Intelligent Systems, 2019
The paper represents a Punjabi corpus in the agriculture domain. There are various dialects in the Punjabi language and the main concentration is on major dialects, i.e. Majhi, Malwai and Doabi for the present study. A speech corpus of 125 isolated words
Arora Shipra J., Singh Rishipal
doaj   +1 more source

Creation and promotion Iranian fisheries research institute laboratories database [PDF]

, 2016
Creating a database of affiliated laboratories of the institute is organized with the aim of integrating information related to laboratories of research centers and their subsidiaries.
Doustdar, M., Esmaeili, F.
core