Results 101 to 110 of about 22,995,424 (299)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Influence of Facility Size on Perioperative Outcomes in Minimally Invasive Esophagectomy for 14 152 Patients With Esophageal Cancer Based on the Japanese National Clinical Database: A Multicenter Cohort Study

Annals of Gastroenterological Surgery
Background Conventional minimally invasive esophagectomy (C‐MIE) is the mainstay for locally advanced esophageal cancer. However, the relationship among facility size, risk‐adjusted mortality and morbidity in C‐MIE remains unclear.
Taro Oshikiri, Hisateru Tachimori, Hiroaki Miyata, Yoshihiro Kakeji, Ken Shirabe   +4 more
doaj   +1 more source

Impact of a Centralized Database System on Radiation Therapy Quality Assurance Management at a Large Health Care Network: 5 Years' Experience. [PDF]

Pract Radiat Oncol, 2022
Tang G, LoSasso T, Chan M, Hunt M.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. [PDF]

Nucleic Acids Res, 2022
Liu L, Li Z, Liu C, Zou D, Li Q, Feng C, Jing W, Luo S, Zhang Z, Ma L.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Enhancements to Human Resource and Data Resource Management Performance in the Development of Disc Brake Pad Products

Engineering Access
The brake friction material sector is impacted by severe competitiveness, continuously changing client needs, and very precise customer specifications. As a result, precise design and quick development are techniques to increase competitiveness.
Preeyanunt Morrakotsriwan, Kritsana Kaewlob, Suntaree Unhapipat, Banpot Horbanluekit, Somkid Amornsamankul   +4 more
doaj  

Research on Elaboration of an Integrated System Based on Xml Data Analysis [PDF]

Informatică economică, 2008
This paper approach the importance of XML for organizing and managing better the data based on texts. This document provides the specification for a data model for describing information organization structures (metadata) for collections of networked ...
Loredana MOCEAN
doaj  

The relational database system of KM3NeT

EPJ Web of Conferences, 2016
The KM3NeT Collaboration is building a new generation of neutrino telescopes in the Mediterranean Sea. For these telescopes, a relational database is designed and implemented for several purposes, such as the centralised management of accounts, the ...
Albert Arnauld, Bozza Cristiano
doaj   +1 more source

Research on the Construction and Application of Breast Cancer-Specific Database System Based on Full Data Lifecycle. [PDF]

Front Public Health, 2021
Jin Y, Junren W, Jingwen J, Yajing S, Xi C, Ke Q.   +5 more
europepmc   +1 more source