Results 51 to 60 of about 9,892,012 (315)
Understanding Collaboration: Introducing the Collaborative Governance Case Databank
Policy & Society, 2020 Studying collaborative governance has become abooming business. However, the empirical literature still struggles to produce robust generalizations and cumulative knowledge that link contextual, situational and institutional design factors to processes ...
Scott Douglas +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Making Medical Education Courses Visible: Theory-Based Development of a National Database
JMIR Medical EducationBackgroundMedical education has undergone professionalization during the last decades, and internationally, educators are trained in specific medical education courses also known as “train the trainer” courses. As these courses have developed organically
Andi Gashi +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Evolution path and the historical roots of nursing theory based on SciMAT and RPYS
Huli yanjiu, 2022 ObjectiveTo sort out nursing theory's evolution path and historical roots and provide a reference for constructing localized nursing theory in China.MethodsThrough the Science Mapping Analysis Software Tool（SciMAT） and the Reference Publication Year ...
ZHU Ruifang +5 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A logic programming e-learning tool for teaching database dependency theory [PDF]
, 2004 In this paper, we describe an "intelligent" tool for helping to teach the principles of database design. The software that we present uses PROLOG to implement a teaching tool with which students can explore the concepts of dependency theory, and the ...
Douglas, P., Barker, S.
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A database of computed Raman spectra of inorganic compounds with accurate hybrid functionals
Scientific DataRaman spectroscopy is widely applied in identifying local structures in materials, but the interpretation of Raman spectra is non-trivial. An accurate computational database of reference spectra calculated with a consistent level of theory can ...
Yuheng Li +5 more
doaj +1 more source
Climates. Habitats. Environments. Database
The Environmentally-Engaged Artistic Practices in South, Southeast Asia and the Pacific Database aspires to provide a comprehensive and rich data source for artists, climate scientists, and policymakers on the artistic practices of artists and ...
Bauer, Ute Meta
core +1 more source