Results 51 to 60 of about 1,690,857 (293)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Towards an Intelligent Database System Founded on the SP Theory of Computing and Cognition

, 2003
The SP theory of computing and cognition, described in previous publications, is an attractive model for intelligent databases because it provides a simple but versatile format for different kinds of knowledge, it has capabilities in artificial ...
Abdelguerfi, Adleman, Adleman, Allison, Anderson, Attneave, Barlow, Barlow, Bertino, Booch, Chater, Chen, Cho, Connolly, J. Gerard Wolff, Laird, Li, Louri, Mahapatra, Newell, Oldfield, Page, Rosenbloom, Sankoff, Solomonoff, Wolff, Wolff, Wolff, Wolff, Wolff, Wolff   +30 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Understanding Collaboration: Introducing the Collaborative Governance Case Databank

Policy & Society, 2020
Studying collaborative governance has become abooming business. However, the empirical literature still struggles to produce robust generalizations and cumulative knowledge that link contextual, situational and institutional design factors to processes ...
Scott Douglas, Chris Ansell, Charles F. Parker, Eva Sørensen, Paul ‘T Hart, Jacob Torfing   +5 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Making Medical Education Courses Visible: Theory-Based Development of a National Database

JMIR Medical Education
BackgroundMedical education has undergone professionalization during the last decades, and internationally, educators are trained in specific medical education courses also known as “train the trainer” courses. As these courses have developed organically
Andi Gashi, Monika Brodmann Maeder, Eva K. Hennel   +2 more
doaj   +1 more source

Evolution path and the historical roots of nursing theory based on SciMAT and RPYS

Huli yanjiu, 2022
ObjectiveTo sort out nursing theory's evolution path and historical roots and provide a reference for constructing localized nursing theory in China.MethodsThrough the Science Mapping Analysis Software Tool（SciMAT） and the Reference Publication Year ...
ZHU Ruifang, DUAN Zhiguang, HAN Shifan, WANG Xiangyu, LIU Chao, LIU Mengyue   +5 more
doaj  

Toric Construction of Global F-Theory GUTs

, 2011
We systematically construct a large number of compact Calabi-Yau fourfolds which are suitable for F-theory model building. These elliptically fibered Calabi-Yaus are complete intersections of two hypersurfaces in a six dimensional ambient space. We first
A Klemm, B Andreas, C Beasley, C Beasley, C-M Chen, C-M Chen, Christoph Mayrhofer, D Cox, H Hayashi, H Hayashi, IM Gelfand, J Marsano, J Marsano, J Marsano, J Marsano, J Tate, Johanna Knapp, K Kodaira, LJ Billera, M Alim, M Cvetič, M Kreuzer, M Kreuzer, M Kreuzer, M Kreuzer, Maximilian Kreuzer, Nils-Ole Walliser, R Blumenhagen, R Blumenhagen, R Blumenhagen, T Oda, T Weigand, TW Grimm, TW Grimm, TW Grimm, TW Grimm, W Fulton   +36 more
core   +4 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source