Results 61 to 70 of about 287,498 (311)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Checking Consistency of Database Constraints [PDF]

, 1986
This paper addresses the problem of consistency of a set of integrity constraints itself, independent from any state. It is pointed out that database constraints have not only to be consistent, but in addition to be finitely satisfiable.
Kambayashi, Yahiko, Bry, François, Manthey, Rainer   +2 more
core   +1 more source

Making Medical Education Courses Visible: Theory-Based Development of a National Database

JMIR Medical Education
BackgroundMedical education has undergone professionalization during the last decades, and internationally, educators are trained in specific medical education courses also known as “train the trainer” courses. As these courses have developed organically
Andi Gashi, Monika Brodmann Maeder, Eva K. Hennel   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evolution path and the historical roots of nursing theory based on SciMAT and RPYS

Huli yanjiu, 2022
ObjectiveTo sort out nursing theory's evolution path and historical roots and provide a reference for constructing localized nursing theory in China.MethodsThrough the Science Mapping Analysis Software Tool（SciMAT） and the Reference Publication Year ...
ZHU Ruifang, DUAN Zhiguang, HAN Shifan, WANG Xiangyu, LIU Chao, LIU Mengyue   +5 more
doaj  

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Playing at Narratology: Digital Media as Narrative Theory [PDF]

, 2019
Introduction: An Archaeology of Narratology -- Narration, Intrigue, and Reader Positioning in Digital Narrative -- Space across Narrative Media -- UI Time and the Digital Event -- Number and Movement in the Construction of Digital Characters -- Algorithm
Punday, Daniel
core   +1 more source

A database of computed Raman spectra of inorganic compounds with accurate hybrid functionals

Scientific Data
Raman spectroscopy is widely applied in identifying local structures in materials, but the interpretation of Raman spectra is non-trivial. An accurate computational database of reference spectra calculated with a consistent level of theory can ...
Yuheng Li, Damien K. J. Lee, Pengfei Cai, Ziyi Zhang, Prashun Gorai, Pieremanuele Canepa   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source