Results 61 to 70 of about 9,614,791 (381)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Providing Sustainable Supply Chain Agility Model in the Brick Industry of Isfahan province [PDF]

open access: yesمدیریت صنعتی, 2018
Objective: Today, manufacturing companies must pay attention to environmental and social issues throughout the supply chain in order to survive. Many efforts have been made to examine the sustainable supply chain, but the agility of sustainable supply ...
Farhad Farhadi   +3 more
doaj   +1 more source

The Google Similarity Distance

open access: yes, 2007
Words and phrases acquire meaning from the way they are used in society, from their relative semantics to other words and phrases. For computers the equivalent of `society' is `database,' and the equivalent of `use' is `way to search the database.' We ...
Cilibrasi, Rudi, Vitanyi, Paul M. B.
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

CLASSIFICATION OF LOGICAL DATA MODELS IMPLEMENTED BY CONTEMPORARY DBMS

open access: yesCifra: Информационные технологии и телекоммуникации
Apart from relational model, many contemporary DBMS implement different data models, including extensions of relational ones. Most of DBMS implement also multiple data models, and are so called “multi-model”.
Tarassov S.
doaj   +1 more source

Inductive Logic Programming in Databases: from Datalog to DL+log

open access: yes, 2010
In this paper we address an issue that has been brought to the attention of the database community with the advent of the Semantic Web, i.e. the issue of how ontologies (and semantics conveyed by them) can help solving typical database problems, through ...
Lisi, Francesca A.
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Understanding Collaboration: Introducing the Collaborative Governance Case Databank

open access: yesPolicy & Society, 2020
Studying collaborative governance has become abooming business. However, the empirical literature still struggles to produce robust generalizations and cumulative knowledge that link contextual, situational and institutional design factors to processes ...
Scott Douglas   +5 more
doaj   +1 more source

A Generative Model for Score Normalization in Speaker Recognition

open access: yes, 2017
We propose a theoretical framework for thinking about score normalization, which confirms that normalization is not needed under (admittedly fragile) ideal conditions. If, however, these conditions are not met, e.g.
Brummer, Niko, Swart, Albert
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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