Results 101 to 110 of about 5,268,956 (336)

A scoping review of human genetic resources management policies and databases in high- and middle-low-income countries

BMC Medical Ethics
Background This review examines global human genetic resources management, focusing on genetic data policies and repositories in high- and middle-low-income countries.
Hongwei Liu, Yin Liu, Yanyan Zhao, Yingqi Ma, Qiong Chen, Huifang Xu, Xiaoyang Wang, Xiaoli Guo, Hong Wang, Zelong Chen, Shaokai Zhang, Binbin Han   +11 more
doaj   +1 more source

dbSNP: the NCBI database of genetic variation [PDF]

Nucleic Acids Research, 2001
In response to a need for a general catalog of genome variation to address the large-scale sampling designs required by association studies, gene mapping and evolutionary biology, the National Center for Biotechnology Information (NCBI) has established the dbSNP database [S.T.Sherry, M.Ward and K. Sirotkin (1999) Genome Res., 9, 677-679].
Jonathan Baker, Stephen T. Sherry, Lon Phan, Karl Sirotkin, Michael Kholodov, Elizabeth M. Smigielski, Minghong Ward   +6 more
openaire   +3 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Is it time for a universal genetic forensic database? [PDF]

Science, 2018
Bias and privacy concerns cloud police use of ...
Bradley A. Malin, James W. Hazel, James W. Hazel, Ellen Wright Clayton, Ellen Wright Clayton, Christopher Slobogin, Christopher Slobogin   +6 more
openaire   +3 more sources

The inherited ataxias: Genetic heterogeneity, mutation databases, and future directions in research and clinical diagnostics

Human Mutation, 2012
The inherited cerebellar ataxias are a diverse group of clinically and genetically heterogeneous neurodegenerative disorders. Inheritance patterns of these disorders can be complex with autosomal dominant, autosomal recessive, X‐linked, and mitochondrial
J. Hersheson, A. Haworth, H. Houlden
semanticscholar   +1 more source

Pl@ntNote: a flexible software for the management and share of data on plants [PDF]

, 2009
A key issue for biodiversity, agronomy and ecological studies is the availability of large and reliable databases on plants. Today, internet tools provide several services that allow the aggregation of various kinds of data into large databases. However,
Birnbaum, Philippe, Molino, Jean-François, Perez, Jérôme, Théveny, Frédéric   +3 more
core  

BacillOndex: An Integrated Data Resource for Systems and Synthetic Biology [PDF]

, 2013
BacillOndex is an extension of the Ondex data integration system, providing a semantically annotated, integrated knowledge base for the model Gram-positive bacterium Bacillus subtilis. This application allows a user to mine a variety of B.
Allenby, Nick, Hallinan, Jennifer S., James, Katherine, Misirli, Goksel, Mullen, Joseph, Pocock, Matthew, Smith, Wendy, Wipat, Anil   +7 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

DNA databanks and consent: A suggested policy option involving an authorization model

BMC Medical Ethics, 2003
Background Genetic databases are becoming increasingly common as a means of determining the relationship between lifestyle, environmental exposures and genetic diseases.
Daar Abdallah, Upshur Ross EG, Caulfield Timothy   +2 more
doaj   +1 more source

Database of genetic studies of bipolar disorder [PDF]

Psychiatric Genetics, 2011
This study describes the construction and preliminary analysis of a database of summary level genetic findings for bipolar disorder from the literature. The database is available for noncommercial use at http://bioprogramming.bsd.uchicago.edu/BDStudies/.
Rajdeep Ranade, John E. Piletz, Chunyu Liu, Xiaotong Zhang   +3 more
openaire   +3 more sources