Results 131 to 140 of about 654,837 (328)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Review of familial hemiplegic migraine, successful outcome in a pregnant patient

Clinical Case Reports, 2019
As the field of neurogenetics is expanding rapidly and variant classification criteria evolve, genetic variants in databases are re‐evaluated overtime allowing updated classifications of pathogenicity predication.
Brent C. Monseur, Hannah B. Anastasio, Andrew Haddad, Huda B. Al‐Kouatly   +3 more
doaj   +1 more source

GA-Novo: De Novo Peptide Sequencing via Tandem Mass Spectrometry using Genetic Algorithm [PDF]

arXiv, 2019
Proteomics is the large-scale analysis of the proteins. The common method for identifying proteins and characterising their amino acid sequences is to digest the proteins into peptides, analyse the peptides using mass spectrometry and assign the resulting tandem mass spectra (MS/MS) to peptides using database search tools.
arxiv  

Pl@ntNote: a flexible software for the management and share of data on plants [PDF]

, 2009
A key issue for biodiversity, agronomy and ecological studies is the availability of large and reliable databases on plants. Today, internet tools provide several services that allow the aggregation of various kinds of data into large databases. However,
Birnbaum, Philippe, Molino, Jean-François, Perez, Jérôme, Théveny, Frédéric   +3 more
core  

Routes for breaching and protecting genetic privacy

, 2013
We are entering the era of ubiquitous genetic information for research, clinical care, and personal curiosity. Sharing these datasets is vital for rapid progress in understanding the genetic basis of human diseases.
A Acquisti, A Cavoukian, A Kong, A Machanavajjhala, A Narayanan, AD Johnson, AJ Pakstis, AK Manning, AL McGuire, Arvind Narayanan, B Fons, B Malin, B Malin, BA Malin, BM Henn, C Dwork, C Shannon, CD Huff, D Clayton, D He, D Zubakov, DJ Solve, DR Nyholt, DW Craig, EA Zerhouni, EE Schadt, EM Ramos, F Liu, G Church, H Lango Allen, H Li, HK Im, HS Venter, J Burn, J Gitschier, J Kaiser, J Kaye, J Kaye, J Lee, J Marchini, JE Lunshof, JH Park, JM Oliver, JP Roberts, K Benitez, K El Emam, K El Emam, K Silventoinen, KA Tryka, KB Jacobs, KS Kendler, L Kamm, L Sweeney, L Sweeney, LA Sweeney, LA Sweeney, LAP Kohn, LL Rodriguez, M Canim, M Gymrek, M Gymrek, M Kantarcioglu, M Kayser, MD Mailman, N Chatterjee, N Homer, NN Taleb, P Bohannon, P Kwok, P Ohm, P Paillier, PM Visscher, R Braun, R Drmanac, R Khan, R Noumeir, RL Bennett, S Byers, S McClure, S Sankararaman, S Walsh, SE Brenner, SF Terry, SH Friend, T Lumley, TE King, TE King, V Bafna, W Fu, W Hartzog, WG Hill, WW Lowrance, XL Ou, Yaniv Erlich, Z Lin   +94 more
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Emotion recognition with 4kresolution database [PDF]

arXiv, 2019
Classifying the human emotion through facial expressions is a big topic in both the Computer Vision and Deep learning fields. Human emotion can be classified as one of the basic emotion types like being angry, happy or dimensional emotion with valence and arousal values.
arxiv  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Data quality measurement on categorical data using genetic algorithm [PDF]

International Journal of Data Mining & Knowledge Management Process (IJDKP) Vol.2, No.1, January 2012, 2012
Data quality on categorical attribute is a difficult problem that has not received as much attention as numerical counterpart. Our basic idea is to employ association rule for the purpose of data quality measurement. Strong rule generation is an important area of data mining.
arxiv  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source