Results 131 to 140 of about 5,268,956 (336)
Genomic and Genetic Database Resources for the Grasses [PDF]
Plant Physiology, 2009 In the strict sense, a biological database is not a Web site. However, the interface that a researcher uses to access the data stored within a database is almost always a Web site. Nonetheless, the two terms are synonymous in the minds of most biologists.
openaire +3 more sources
Evolving structure-function mappings in cognitive neuroscience using genetic programming [PDF]
, 2005 A challenging goal of psychology and neuroscience is to map cognitive functions onto neuroanatomical structures. This paper shows how computational methods based upon evolutionary algorithms can facilitate the search for satisfactory mappings by ...
Gobet, F, Parker, A
core +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Genotator: A disease-agnostic tool for genetic annotation of disease
BMC Medical Genomics, 2010 Background Disease-specific genetic information has been increasing at rapid rates as a consequence of recent improvements and massive cost reductions in sequencing technologies.
Jung Jae-Yoon +6 more
doaj +1 more source
SIG-DB: leveraging homomorphic encryption to Securely Interrogate privately held Genomic DataBases
, 2018 Genomic data are becoming increasingly valuable as we develop methods to utilize the information at scale and gain a greater understanding of how genetic information relates to biological function.
Flower, Audrey +8 more
core +2 more sources
Evolutionary biology for the 21st century [PDF]
, 2013 New theoretical and conceptual frameworks are required for evolutionary biology to capitalize on the wealth of data now becoming available from the study of genomes, phenotypes, and organisms - including humans - in their natural environments.Molecular ...
Arnold, Stevan J. +14 more
core +5 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The Genetic Landscape of Diamond-Blackfan Anemia
bioRxiv, 2018 Diamond-Blackfan anemia (DBA) is a rare bone marrow failure disorder that affects 1 in 100,000 to 200,000 live births and has been associated with mutations in components of the ribosome. In order to characterize the genetic landscape of this genetically
J. Ulirsch +41 more
semanticscholar +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Genetics & Genomic Medicine, 2020 Background Biallelic pathogenic variants in CBS gene cause the most common form of homocystinuria, the classical homocystinuria (HCU). The worldwide prevalence of HCU is estimated to be 0.82:100,000 [95% CI, 0.39–1.73:100,000] according to clinical ...
Giovana R. Weber Hoss +3 more
doaj +1 more source