Results 51 to 60 of about 654,837 (328)

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

Nature Communications, 2016
Current databases of V genes for antibody repertoire have limitations. Here Corcoran et al. develop a computational approach named IgDiscover that can identify germline V gene sequences from expressed antibody repertoires to high specificity and ...
Martin M. Corcoran, Ganesh E. Phad, Néstor Vázquez Bernat, Christiane Stahl-Hennig, Noriyuki Sumida, Mats A.A. Persson, Marcel Martin, Gunilla B. Karlsson Hedestam   +7 more
doaj   +1 more source

A Semi-Supervised Generative Adversarial Network for Prediction of Genetic Disease Outcomes [PDF]

arXiv, 2020
For most diseases, building large databases of labeled genetic data is an expensive and time-demanding task. To address this, we introduce genetic Generative Adversarial Networks (gGAN), a semi-supervised approach based on an innovative GAN architecture to create large synthetic genetic data sets starting with a small amount of labeled data and a large
arxiv  

Towards a bioinformatics platform for the Musa research community : [Abstract W076] [PDF]

, 2010
Current experiments in genomics produce a large amount of data that needs to be organized into databases and broadly accessible. Like other species, the Musa genomics community would benefit from centralized and innovative ways to study its genome.
Argout, Xavier, Bocs, Stéphanie, Conte, Matthieu, Droc, Gaëtan, Guignon, Valentin, Hamelin, Chantal, Rouard, Mathieu, Roux, Nicolas, Ruiz, Manuel   +8 more
core  

BioCloud Search EnGene: Surfing Biological Data on the Cloud [PDF]

, 2014
The massive production and spread of biomedical data around the web introduces new challenges related to identify computational approaches for providing quality search and browsing of web resources.
DESSI, NICOLETTA, MILIA, GABRIELE, Pascariello E, PES, BARBARA   +3 more
core   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

GMO Genetic Elements Thesaurus (GMO-GET): a controlled vocabulary for the consensus designation of introduced or modified genetic elements in genetically modified organisms

BMC Bioinformatics, 2021
Background Various databases on genetically modified organisms (GMOs) exist, all with their specific focus to facilitate access to information needed for, e.
Paulien Adamse, Emilie Dagand, Karen Bohmert-Tatarev, Daniela Wahler, Manoela Miranda, Esther J. Kok, Joachim Bendiek   +6 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

DNA databanks and consent: A suggested policy option involving an authorization model

BMC Medical Ethics, 2003
Background Genetic databases are becoming increasingly common as a means of determining the relationship between lifestyle, environmental exposures and genetic diseases.
Daar Abdallah, Upshur Ross EG, Caulfield Timothy   +2 more
doaj   +1 more source

Multilevel Modeling with Structured Penalties for Classification from Imaging Genetics data [PDF]

3rd MICCAI Workshop on Imaging Genetics (MICGen 2017), Graphs in Biomedical Image Analysis, Computational Anatomy and Imaging Genetics, Lecture Notes in Computer Science, 1 (21), pp.230-240, Qu\'ebec City, Canada. Springer, 2017, 2017
In this paper, we propose a framework for automatic classification of patients from multimodal genetic and brain imaging data by optimally combining them. Additive models with unadapted penalties (such as the classical group lasso penalty or $L_1$-multiple kernel learning) treat all modalities in the same manner and can result in undesirable ...
arxiv   +1 more source