Results 251 to 260 of about 453,721 (346)

On the origin of reverse transcriptase-using CRISPR-Cas systems and their hyperdiverse, enigmatic spacer repertoires [PDF]

, 2017
et al,, Krishnamurthy, Siddharth R, Wang, David   +2 more
core   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Inhalable gene and RNA therapy for cystic fibrosis: perspectives and progress in clinical development. [PDF]

Nanomedicine (Lond)
Munir M, Butcher NJ, Werder RB, Ranganathan SC, Burow R, Venables A, Kaminskas LM.   +6 more
europepmc   +1 more source

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural products for biomedical research. [PDF]

Nucleic Acids Res
Lin H, Hou D, Jiang X, Yin R, Yu S, Lu S, Wang S, Ju D, Zhao H, Chen Y, Zeng X.   +10 more
europepmc   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Expert consensus on the detection and clinical application of tumor mutational burden. [PDF]

Cancer Biol Med
Guo Z, Xu C, Zhang S, Hao Y, Hu X, Zhao M, Xiang C, Piao Y, Sun P, Xiang X, Zhao J, Wu H, Li W, Yu J, Yuan J, Wang S, Wang C, Gu Y, Lv B, Zhang L, Liu Y, Cui X, Gu W, Li Y, Wang W, Yang W, Long W, Xiang J, Mou H, Liu B, Ruan H, Wang Y, Zhu Y, Wang F, Wang Z, Feng X, Liu X, Li P, Deng M, Lian B, Mao L, Wang Q, Wang W, Song Z, Li Z, Zhong W, Wang Z, Ren S, Fang W, Zhang Y, Liu J, Cai X, Liu A, Li W, Zhan P, Liu H, Lv T, Miao L, Min L, Chen Y, Zhang Y, Wang F, Jiang Z, Lin G, Huang L, Pu X, Lin R, Liu W, Rao C, Lv D, Yu Z, Shen P, Li X, Tang C, Zhou C, Zhang J, Xue J, Guo H, Chu Q, Meng R, Wu J, Zhang R, Zhou J, Zhu Z, Li Y, Qiu H, Xia F, Lu Y, Chen X, Ge R, Dai E, Han Y, Zhang J, Ji Y, Liang X, Zhang H, Ma X, Liu X, Yao Y, Luo P, Pan W, Pang F, Wu F, Gu D, Wang L, Wang L, Zhu Y, Lin L, Li W, Lin X, Cai J, Xu L, Li J, Jiao X, Li K, Wei J, Feng H, Wang L, Du Y, Yao W, Shi X, Niu X, Yuan D, Yao Y, Zhang Y, Song B, Li W, Fu J, Wang H, Ye M, Wang D, Wang Z, Ji Q, Fang Y, Wei Q, Wang Z, Wan B, Lv D, Li X, Yang S, Kang J, Zhang J, Zhang C, Shi L, Wang Y, Li B, Zhang Z, Wang K, Liu Z, Yang N, Wu L, Chen X, Jin G, Li Z, Li M, Wang G, Wang J, Fang M, Fang Y, Wang X, Chen J, Zhang Y, Zhu X, Shen Y, Ma S, Wang B, Si L, Song Y, Lu Y, Liu A, Han Y.   +170 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

QSProteome: a community-driven interactive platform for large-scale exploration and evaluation of predicted protein complex structures. [PDF]

Nucleic Acids Res
Catoiu EA, Kambo D, Rodriguez B, Vear K, Wang Z, Akpata J, Shah J, Ayoub R, Hofmann M, Ananda K, Tantry A, Gupta I, Anwyl R, Faucher C, Nichols J, Ton B, Marchal LO, Palsson BO.   +17 more
europepmc   +1 more source

Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology

Biotechnology and Bioengineering, EarlyView.
ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman, Emily Lathrop, Aurelia Attal‐Juncqua, Matthew Nicotra, Allison Berke   +4 more
wiley   +1 more source