Advanced Healthcare Materials, EarlyView.This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen +7 more
wiley +1 more source
Exploring the global mosaic of medicinal plant databases: unveiling nature's pharmacopoeia. [PDF]
Nat Prod BioprospectJiang Y, Jia X, Yang Z.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou +9 more
wiley +1 more source
Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks. [PDF]
Proc Natl Acad Sci U S ASaha A, Tang CL, Murray D, Honig B.
europepmc +1 more source
Double‐Transition‐Metal MXenes: Multimetallic 2D Platforms for Next‐Generation Biomedicine
Advanced Materials, EarlyView.The present work explores recent progress in double‐transition‐metal MXenes and focuses on their potential as multifunctional biomedical nanoplatforms whose tunable optical, electronic, mechanical, and surface properties enable imaging, theranostics, antimicrobial activity, biosensing, tissue engineering, and drug delivery.
Parsa Namakiaraghi +2 more
wiley +1 more source
Multi-scale analysis reveals key targets mediating BPA-induced sensorineural hearing loss. [PDF]
Medicine (Baltimore)Yan X, Xuan J, Peng J.
europepmc +1 more source
Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets
Advanced Materials Technologies, EarlyView.This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu +7 more
wiley +1 more source
iCRCexp: An Integrative Database for Colorectal Cancer-Associated Gene Expression Profiles. [PDF]
Cancer InformYuan Y +8 more
europepmc +1 more source
Advanced Materials Technologies, EarlyView.This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li +7 more
wiley +1 more source
Development and Validation of an Algorithm for Constructing an Amino Acid Database for Application to the Korean Genome and Epidemiology Study Cohort. [PDF]
NutrientsLee SJ, Hwang JY.
europepmc +1 more source