Results 141 to 150 of about 187,791 (308)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

2016 IRIS\uae Registry summary data report for the Vision & Eye Health Surveillance System [PDF]

Compiled by the American Academy of Ophthalmology (AAO), IRIS\uae Registry (Intelligent Research In Sight) is the nation\u2019s first comprehensive eye disease clinical registry.

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Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Document sentiment modeling based on topic attention hierarchy memory network

四川大学学报. 自然科学版, 2019
To the problem of prior knowledge and lack of semantic understanding in the traditional model of document level sentiment analysis, this paper proposes an sentiment analysis model called TWEANN（Attention Neural Networks based on Topicenhanced Word ...
liuguangfeng, huangxianying, liuxiaoyang, fanhaibo   +3 more
doaj  

Improving Suicidal Ideation Detection in Social Media Posts: Topic Modeling and Synthetic Data Augmentation Approach

JMIR Formative Research
BackgroundIn an era dominated by social media conversations, it is pivotal to comprehend how suicide, a critical public health issue, is discussed online.
Hamideh Ghanadian, Isar Nejadgholi, Hussein Al Osman   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

2014-15 Medicare summary data report for the Vision & Eye Health Surveillance System [PDF]

We included beneficiaries who were fully enrolled in Medicare Part B Fee-for-Service (FFS) for the duration of 2014 and 2015 in the analysis of Medicare claims for the Vision and Eye Health Surveillance System (VEHSS).

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Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

ACS summary data report for the Vision & Eye Health Surveillance System [PDF]

This Data Brief Report presents the analysis of the American Community Survey (ACS) for the Vision and Eye Health Surveillance System (VEHSS). This document describes the methods used to construct the estimates.

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