Results 131 to 140 of about 187,791 (308)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
2016 VSP summary data report for the Vision & Eye Health Surveillance System [PDF]
VSP Global is the nation\u2019s largest vision insurance provider, operating as a nonprofit corporation for 60 years. Vision insurance is a specialized supplemental insurance provided through employers, commercial health plans, Medicare/Medicaid ...
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
TATA: Stance Detection via Topic-Agnostic and Topic-Aware Embeddings [PDF]
Stance detection is important for understanding different attitudes and beliefs on the Internet. However, given that a passage's stance toward a given topic is often highly dependent on that topic, building a stance detection model that generalizes to ...
Durumeric, Zakir, Hanley, Hans W. A.
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
NHIS summary data report for the Vision & Eye Health Surveillance System [PDF]
The main objective of the National Health Interview Survey (NHIS) is to monitor the health of the United States population through the collection and analysis of data on a broad range of health topics.
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
GINopic: Topic Modeling with Graph Isomorphism Network [PDF]
Topic modeling is a widely used approach for analyzing and exploring large document collections. Recent research efforts have incorporated pre-trained contextualized language models, such as BERT embeddings, into topic modeling.
Adhya, Suman, Sanyal, Debarshi Kumar
core +1 more source
From Digital Library to Open Datasets: Embracing a "Collections as Data" Framework [PDF]
, 2019 This article discusses the burgeoning “collections as data” movement within the fields of digital libraries and digital humanities. Faculty at the University of Utah’s Marriott Library are developing a collections as data strategy by leveraging existing ...
Cummings, Rebekah +3 more
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