Results 111 to 120 of about 187,791 (308)

Discovering Topic Representative Terms for Short Text Clustering

open access: yesIEEE Access, 2019
Clustering short texts are one of the most important text analysis methods to help extract knowledge from online social media platforms, such as Twitter, Facebook, and Weibo.
Shuiqiao Yang, Guangyan Huang, Borui Cai
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A New Algorithm of Mining High Utility Sequential Pattern in Streaming Data

open access: yesInternational Journal of Computational Intelligence Systems, 2019
High utility sequential pattern (HUSP) mining has emerged as a novel topic in data mining, its computational complexity increases compared to frequent sequences mining and high utility itemsets mining.
Huijun Tang, Yangguang Liu, Le Wang
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Strategies for Improving Semi-automated Topic Classification of Media and Parliamentary documents [PDF]

open access: yes, 2009
Since 1995 the techniques and capacities to store new electronic data and to make it available to many persons have become a common good. As of then, different organizations, such as research institutes, universities, libraries, and private companies ...
Then, H.   +5 more
core  

Neural topic model with reinforcement learning [PDF]

open access: yes, 2019
In recent years, advances in neural variational inference have achieved many successes in text processing. Examples include neural topic models which are typically built upon variational autoencoder (VAE) with an objective of minimising the error of ...
Pergola, Gabriele   +11 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Improving Contextualized Topic Models with Negative Sampling [PDF]

open access: yes, 2023
Topic modeling has emerged as a dominant method for exploring large document collections. Recent approaches to topic modeling use large contextualized language models and variational autoencoders.
Adhya, Suman   +3 more
core   +1 more source

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