Results 91 to 100 of about 13,448,515 (313)

The day-to-day co-production of ageing in place [PDF]

, 2014
We report findings from a study that set out to explore the experience of older people living with assisted living technologies and care services. We find that successful ‘ageing in place’ is socially and collaboratively accomplished – ‘co-produced ...
Wherton, Joe, Joe Wherton, Trisha Greenhalgh, Hinder, Sue, Rouncefield, Mark, Rob Procter, Greenhalgh, Trisha, Procter, Rob, Paul Sugarhood, Sue Hinder, Mark Rouncefield, Sugarhood, Paul, Wherton, J, Rouncefield, M, Greenhalgh, T, Hinder, S, Sugarhood, P, Procter, R   +17 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Family day care in the United States /

, 1981
"Issued September 1981."At head of title: National day care home study final report : executive summary.Cover title: Family day care in the United States : executive summary.Mode of access ...
Divine-Hawkins, Patricia., United States. Administration for Children, Youth, and Families. Day Care Division.   +1 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

What is the existing evidence base for adult medical Same Day Emergency Care in UK NHS hospitals? A scoping review

Future Healthcare Journal
Introduction: This scoping review focuses on acute medical Same Day Emergency Care (SDEC), as medical patients represent a significant proportion of emergency admissions in the NHS.
Sue Dean, Julian Barratt
doaj   +1 more source

Point-of-care Head and Neck Sonography for Clinical Problem-solving: Impact of One-day Training Sessions on Medical Student Education

, 2018
Introduction The curriculum for medical student education is continuously evolving to emphasize knowledge acquisition with critical problem-solving skills. Medical schools have started to implement curricula to teach point-of-care ultrasound skills.
Stolz, Lori A, Situ-LaCasse, Elaine, Sterling, Robert, Sanders, Arthur B, Jung, Chan, Amini, Richard, Acuna, Josie, Friedman, Lucas, Adhikari, Srikar, Irving, Steven C   +9 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Health Care Waste Management Practice in Health Care Institutions of Nepal

Journal of Nepal Health Research Council, 2017
Background: Medical waste is considered as a major public health hazard. In a developing country like Nepal, there is much concern about the management practice of medical waste.
Hari Datt Joshi, Trishna Acharya, Purushottam Dhakal, Rakesh Ayer, Khem Bahadur Karki, Meghnath Dhimal   +5 more
doaj   +1 more source

Midland Health Board. Community Care Programme. Community Care Services report 1989 [PDF]

, 1989
Services for the Elderly in tbe Midland Health Board area are provided by both the Hospital Care Programme and the Community Care Programme. In addition to the medical, nursing and home help services (which will be dealt with separately in the Annual
Midland Health Board. Community Care Programme.
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source