Results 31 to 40 of about 837,134 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Design Method of Double-Boost DC/DC Converter with High Voltage Gain for Electric Vehicles
World Electric Vehicle Journal, 2020 Direct current to direct current (DC/DC) converters are required to have higher voltage gains in some applications for electric vehicles, high-voltage level charging systems and fuel cell electric vehicles. Therefore, it is greatly important to carry out
Zhengxin Liu, Jiuyu Du, Boyang Yu
doaj +1 more source
Soft-Switching Full-Bridge DC-DC Converter with Energy Recovery Capacitor Snubber
Energies, 2023 This paper describes a high-frequency soft-switching dc-dc converter with a simple energy recovery capacitor snubber on the secondary side. The presented dc-dc full-bridge converter with the energy recovery snubber removes the main drawbacks of the ...
Marek Pastor +3 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Measurement-based modeling of a DC-DC converter for the bill of material prediction [PDF]
, 2022 The topic of the project is the modeling of a DC-DC converter that allows to predict its behavior. The idea is to create a systematic methodology that reduces the amount of time, costs and complexity of the stability assessment.
Bianchi, Luca
core
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Design of an AC/DC Converter with using Supercapacitors as Energy Storage
RMUTL Engineering Journal, 2016 This paper presents a design of a high power factor AC/DC converter with using supercapacitors as energy storage.The proposed system consists of a cuk topology based AC/DC power converter and a bidirectional DC/DC converter which is connected between the
พิสิทธิ วิสุทธิเมธีกร +1 more
doaj
Design and Implementation of Series Resonant DC-DC Converter
Jurnal Nasional Teknik Elektro, 2020 The resonant DC-DC converter is known as advantageous over conventional DC-DC converter in terms of efficiency. This is primarily because the resonant converter operates at soft switching mode.
Firmansyah Nur Budiman, Arridha Amrad
doaj +1 more source