Results 51 to 60 of about 1,075,155 (309)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Plant Protection Research, 2017 The olive fruit fly Bactrocera oleae is one of the most serious and economically damaging insects worldwide, affecting the quality and quantity of both olive oil and table olives.
Torrini Giulia +3 more
doaj +1 more source
Protection analysis for plant rating and power quality issues in LVDC distribution power systems [PDF]
, 2015 Low Voltage DC (LVDC) distribution systems have the potential to be considered as an efficient platform for facilitating the connection of more distributed energy resources.
Burt, Graeme, Emhemed, Abdullah
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Key issues in application of composites to transport aircraft [PDF]
, 1978 The application of composite materials to transport aircraft was identified and reviewed including the major contributing disciplines of design, manufacturing, and processing.
Stone, M.
core +1 more source
On the Optimality of Virtualized Security Function Placement in Multi-Tenant Data Centers [PDF]
, 2018 Security and service protection against cyber attacks remain among the primary challenges for virtualized, multi-tenant Data Centres (DCs), for reasons that vary from lack of resource isolation to the monolithic nature of legacy middleboxes.
Ali, Abeer +2 more
core +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
New-Generation Sequencing Technology in Diagnosis of Fungal Plant Pathogens: A Dream Comes True?
Journal of Fungi, 2022 The fast and continued progress of high-throughput sequencing (HTS) and the drastic reduction of its costs have boosted new and unpredictable developments in the field of plant pathology.
Maria Aragona +7 more
doaj +1 more source
Novel short‐circuit protection technique for DC–DC buck converters
IET Circuits, Devices & Systems, 2014 This study presents a novel short‐circuit protection technique for DC–DC buck converters. The required short‐circuit operating frequency is derived in order to avoid the effect of inherent propagation delay in the controller and power transistors.
Yajun Li +3 more
openaire +1 more source