Results 41 to 50 of about 759,653 (297)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Calculation and control of DC bias current distribution in an AC power system around a typical ±800 kV DC grounding electrode

The Journal of Engineering, 2019
When the ultra-high-voltage direct current (UHVDC) transmission system operates in a monopolar ground return mode, an enormous DC current flows into earth via the DC grounding electrode in the converter station and then comes into the AC system around ...
Fangjie Wu, Shifeng Yu, Zheng Zhao, Wanlin Quan   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Design of high voltage and large capacity DC transformers based on capacitive power transfer principle

Zhejiang dianli
DC transformers serve as critical infrastructure for interconnecting DC systems at different voltage levels and constructing DC power grids. The development of cost-effective， high-efficiency， and lightweight DC transformers remains a pivotal research ...
XI Guangyu, XU Jianjun, ZHU Jingpeng
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Bragg grating based integrated photonic Hilbert transformers

, 2013
Planar Bragg grating based photonic Hilbert transformers are experimentally demonstrated in this work. Planar Bragg gratings are utilized to implement a general Hilbert transform, a fractional order Hilbert transform and terahertz bandwidth Hilbert ...
Smith, P.G.R., Sima, C., Gates, J.C., Zervas, M.N.   +3 more
core   +2 more sources

A versatile series‐parallel‐connected bidirectional DC power flow controller for HVDC and MVDC system

IET Generation, Transmission & Distribution, 2023
This paper proposes a transformer type dc power flow controller (DCPFC) based on stacks composed of sub‐modules (SMs). The converter can perform dc power flow control independently on point‐to‐point as well as multi‐terminal connection, which can be ...
Jiuyang Jin, Xiaotian Zhang, Zhilin Xiao, Yanan Ye, Xueao Qiu, Xu Yang   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Research on Current Limiting Method Used for Short Circuit Fault Current of Resonant DC Transformer Based on Inverted Displacement Phase Control

IEEE Access, 2020
Due to the characteristics of high efficiency and flexible transformation ratio, full-bridge CLLC resonant DC transformers have been increasingly used for DC grid in recent years.
Chaoran Zhuo, Xu Yang, Xiaotian Zhang, Xiong Zhang   +3 more
doaj   +1 more source

Reduction of geomagnetically induced current impacts by optimized neutral point connections

IET Generation, Transmission & Distribution, 2023
Solar storms impact electrical power grids by causing quasi‐DC neutral point currents in transformers. These currents lead to half‐cycle saturation as well as other related and unwanted effects in the grid.
Philipp Schachinger, Dennis Albert, Herwig Renner   +2 more
doaj   +1 more source