Results 91 to 100 of about 2,927 (248)

Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment [PDF]

, 2016
There are two known mRNA degradation pathways, 3′ to 5′ and 5′ to 3′. We identified likely pathogenic variants in two genes involved in these two pathways in individuals with intellectual disability.
Bhatti, Attya, Jiao, Xinfu, Brohi, M. Qasim, Zhou, Mi, Mittal, Kirti, Ayub, Muhammad, Reis, André, Buchert, Rebecca, Kiledjian, Megerditch, Ayaz, Muhammad, Sheikh, Taimoor I., Jamra, Rami Abou, Carter, Melissa T., Vincent, John B., Ahmed, Iltaf, Vasli, Nasim, Rafiq, Muhammad Arshad, Nasr, Tanveer, Uebe, Steffen, Mikhailov, Anna, Scheller, Ute, Sticht, Heinrich, John, Peter   +22 more
core   +1 more source

Understanding Mammalian Habitat Use With a Multi‐Species, Multi‐Scale Approach: The Jaguar Protection Corridor in Guaviare, Colombia

Animal Conservation, EarlyView.
We applied a multi‐scale, multi‐species framework to quantify how landscape structure and human infrastructure influence habitat use across a terrestrial mammal community within a biological corridor in the Colombian Amazon. Forest cover and spatial configuration influenced wildlife habitat use at spatial scales associated with species dispersal ...
Gabriel P. Andrade‐Ponce, Eduardo Molina‐González, Jaime Andrés Cabrera   +2 more
wiley   +1 more source

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)

, 2017
The C-5 substituted 2,4-diaminoquinazoline RG3039 (compound 1), a member of a chemical series that was identified and optimized using an SMN2 promoter screen, prolongs survival and improves motor function in a mouse model of spinal muscular atrophy (SMA).
Arjun Narayanan (197239), Mihir D. Parikh (3840538), Jonathan J. Cherry (501180), Lyn H. Jones (465244), Paula M. Loria (1600666), Joseph F. Nabhan (3840535), Olugbeminiyi Fadeyi (3840547), Haojing Rong (2138929), Ariamala Gopalsamy (1616713), Robert E. Kyne (1616719), Yong Ren (86476), Gregory LaRosa (2641600), Timothy L. Foley (1307850), Michael A. Tones (1616704), Shenping Liu (1485079), Jodi Maglich-Goodwin (3840550), Donna N. Petersen (3840544), Stephen Noell (701427), Carol Menard (3840541)   +18 more
core   +1 more source

Adult‐onset Coats disease: A systematic review and meta‐analysis of imaging biomarkers and targeted therapies

Acta Ophthalmologica, EarlyView.
Abstract Coats disease diagnosed in adulthood is a rare idiopathic retinal telangiectatic vasculopathy that may differ in phenotype from childhood‐diagnosed cases. This systematic review synthesizes current evidence to characterize its clinical spectrum, imaging features, treatment outcomes and underlying mechanisms, with a focus on immunovascular ...
Catarina Francisco, Nisa Silva, Camiel J. F. Boon   +2 more
wiley   +1 more source

DCPS: Limitation of Attorneys' Fees for Fiscal Years 1999 through 2001 [PDF]

, 2002
Correspondence issued by the General Accounting Office with an abstract that begins "The District of Columbia appropriations acts for fiscal years 1999, 2000, and 2001 limited the amount of appropriated funds that could be paid to an attorney ...
United States. General Accounting Office.
core  

GO term classification of the DCPs between the patients and CK with p-values < 0.01.

, 2016
GO term classification of the DCPs between the patients and CK with p-values < 0.01.
Wenbin Wei (150871), Xudong Song (3152823), Qiong Yang (28822), Hai Lu (2155717), Songfeng Li (3152820)   +4 more
core   +1 more source

Inter‐eye microvascular asymmetry across stages of diabetic retinopathy: An OCT angiography study

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate inter‐eye asymmetry in macular microvascular parameters across different stages of diabetic retinopathy (DR) using OCT angiography, and to explore the associations with clinical factors. Methods This cross sectional study included 442 eyes of 221 patients with diabetes mellitus type 2. Central subfield thickness (CST), area
Stela Vujosevic, Sema Tamer Kaderli, Gabriele Piccoli, Elena Tagliabue, Camilla Alovisi, Vanda Bucceri, Emanuele Torti, Elisa Marenzi, Dogukan Ozen, Livio Luzi, Paolo Nucci   +10 more
wiley   +1 more source

Optic nerve head blood flow autoregulation during isometric exercise in primary open‐angle glaucoma assessed by laser speckle flowgraphy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess optic nerve head blood flow (ONHBF) autoregulation in patients with early‐ to moderate‐stage primary open‐angle glaucoma (POAG) and age‐ and sex‐matched healthy controls using laser speckle flowgraphy (LSFG) and isometric handgrip exercise.
Theresa Lindner, Viktoria Pai, Patrick Janku, Nikolaus Hommer, Anton Hommer, Liudmyla Petric, Ulrich Graf, Leopold Schmetterer, Gerhard Garhöfer, Doreen Schmidl   +9 more
wiley   +1 more source

Forty-six DCPs, including 29 down-regulated proteins (log FC < -1) and 17 up-regulated proteins (log FC > 1).

, 2016
Forty-six DCPs, including 29 down-regulated proteins (log FC 1).
Wenbin Wei (150871), Xudong Song (3152823), Qiong Yang (28822), Hai Lu (2155717), Songfeng Li (3152820)   +4 more
core   +1 more source

Correcting Axial Length‐Related Magnification Errors in Optical Coherence Tomography Angiography Improves Machine Learning Classification Performance in High Myopia

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To determine whether axial length‐related magnification correction in optical coherence tomography angiography (OCTA) improves machine learning classification of high myopia and resolves inconsistencies in the values and discriminatory power of OCTA microvascular metrics.
Danuta M. Sampson, Mila Yue Zhang, Hemn Baghban Jaldian, Madeleine S. Torcasso, Gavrielle R. Untracht, Jocelyn J. Drinkwater, Mei Zhao, David D. Sampson, Andrew Lam, Fred K. Chen   +9 more
wiley   +1 more source