Results 121 to 130 of about 112,080 (220)

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

Epilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed, Lauren M. Aiani, Eesha Faiz, Emmanuel Adediran, Morris Benveniste, Kevin S. Murnane, Martin D'Souza, Andrew Escayg, Jennifer C. Wong   +8 more
wiley   +1 more source

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels. [PDF]

Nat Commun
Handklo-Jamal R, Raifman TK, Shalomov B, Hofer P, Kahanovitch U, Friesacher T, Tabak G, Tsemakhovich V, Reddy HP, Chomsky-Hecht O, Tripathy DR, Zuhlke K, Dessauer CW, Klussmann E, Haitin Y, Hirsch JA, Stary-Weinzinger A, Yakubovich D, Dascal N.   +18 more
europepmc   +2 more sources

Emission Using Adaptable Range Separated Hybrids: Thermally Activated Delayed Fluorescence Emitters as Test Case. [PDF]

J Comput Chem
Yan T, Adamo C, Ciofini I.
europepmc   +1 more source

Equine trypanosomiasis, a systematic review and meta‐analyses: Prevalence, morbidity and mortality

Equine Veterinary Journal, EarlyView.
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Alexandra G. Raftery, Lauren Gummery, Karelhia Garcia, Dinesh Mohite, Paul Capewell, David G. M. Sutton   +5 more
wiley   +1 more source

Visceral Peritoneum Hyperpigmentation in Chickens Is Associated with <i>DCT</i> Expression. [PDF]

Animals (Basel)
Dong X, Liu Q, Xing J, Mo G, Li M, Nie Q, Shu J, Li Z.   +7 more
europepmc   +1 more source

TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation

The FEBS Journal, EarlyView.
TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni, Lucia Merolle, Agnese Razzoli, Eleonora Maurizi, Gaia Gavioli, Roberto Baricchi, Chiara Marraccini, Davide Schiroli   +7 more
wiley   +1 more source

Assessing reporting completeness and characteristics in decentralized randomized controlled trials: a scoping review protocol. [PDF]

Syst Rev
Wang J, Li S, Zhao C, Wang J, Xiong W, Hu L, Zhang X.   +6 more
europepmc   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Effect of Deep Cryogenic Treatment on Aging Strength of Mg-Al-Ca-Mn Alloy. [PDF]

Materials (Basel)
Fouad M, Nakata T, Xu C, Zuo J, Wu Z, Geng L.   +5 more
europepmc   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source