Results 1 to 10 of about 64,857 (161)

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

From the Field to the Laboratory: The Theory‐Practice Research of Peter J. Carnevale

Negotiation and Conflict Management Research, EarlyView., 2020
Abstract As colleagues and collaborators, we reflect on the work and legacy of Peter Carnevale, currently professor at the University of Southern California, and recipient of the 2002 Jeffrey Z. Rubin Theory‐to‐Practice Award of the International Association for Conflict Management (IACM). We review Carnevale’s main contributions, including his work on
Linda L. Putnam, Mara Olekalns, Donald E. Conlon, Carsten K. W. De Dreu   +3 more
wiley   +1 more source

The Role of Artificial Intelligence in Medication Management for Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Artificial intelligence enhances medication management for older adults by improving adherence, personalizing treatment, and predicting risks. Despite benefits, challenges remain in usability, trust, ethics, and system integration. Successful adoption requires user‐centered design, ethical safeguards, and seamless healthcare integration to ensure safe,
Dipak Chandra Das, Moustaq Karim Khan Rony, Shovit Dutta, MD. Sami Al Zubair Zujbe, Tapan Bhattacharjee, Niloy Debnath, Shabbir Abdullah Maruf, Chowdhury Galib Mortuza, Farhana Rahman, Akash Das   +9 more
wiley   +1 more source

The Bitter Taste of Brazil's Temporary Import Ban on Robusta Coffee

Agribusiness, EarlyView.
ABSTRACT Brazil, a leading Robusta coffee producer and exporter, faced a significant drought in 2016–2017, which drastically reduced production and depleted stocks. Consequently, Brazil temporarily permitted the import of one million 60‐kg bags of Robusta coffee in the spring 2017. An import ban was imposed shortly afterward due to lobbying by domestic
Hanifi Otgun, John Beghin, Fernando Maximiliano   +2 more
wiley   +1 more source

Prospecting of Architectural Features Using LiDAR‐UAV Technology, Deep Neural Networks and Visualization Techniques: A Case Study in Kuélap and Cambolín (NW Peru)

Archaeological Prospection, EarlyView.
ABSTRACT High‐resolution and accurate synoptic images of terrestrial topography, even in densely forested areas, have proven valuable for archaeology by enabling the identification and characterization of relief patterns associated with ancient human activities. This study presents a novel approach that integrates digital terrain models (DTMs) obtained
Jhon A. Zabaleta‐Santisteban, Rolando Salas López, Angel J. Medina‐Medina, Katerin M. Tuesta‐Trauco, Abner S. Rivera‐Fernandez, Nerci M. Noriega‐Salazar, José A. Sánchez‐Vega, Teodoro B. Silva‐Melendez, Marlen A. Grandez‐Alberca, Jhonsy O. Silva‐López, Nilton B. Rojas‐Briceño, Manuel Oliva‐Cruz, Alexander Cotrina‐Sanchez, Elgar Barboza   +13 more
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Digital Dynamic Capabilities and Environmental Sustainability: The Role of Circular Supply Chain Practices

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study explores how digital dynamic capabilities (DDC)—specifically digital absorptive capacity (DAC) and digital transformation capacity (DTC)—contribute to environmental sustainability (ES), both directly and through circular supply chain practices (CSCP).
Yi Liang, Tae‐Hoo Kim, Min‐Jae Lee
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source