Results 41 to 50 of about 64,857 (161)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Investigating the feasibility of a distributed, mapping-based, approach to solving subject interoperability problems in a multi-scheme, cross-service, retrieval environment [PDF]

, 2006
The HILT project is researching the problems of facilitating interoperability of subject descriptions in a distributed multi-scheme environment. HILT Phase I found a UK community consensus in favour of utilising an inter-scheme mapping service to improve
McCulloch, Emma, Nicholson, Dennis
core   +1 more source

Intersecting Solitons, Amoeba and Tropical Geometry

, 2008
We study generic intersection (or web) of vortices with instantons inside, which is a 1/4 BPS state in the Higgs phase of five-dimensional N=1 supersymmetric U(Nc) gauge theory on R_t \times (C^\ast)^2 \simeq R^{2,1} \times T^2 with Nf=Nc Higgs scalars ...
A. A. Abrikosov, A. A. Abrikosov, B. Sturmfels, D. N. Bernstein, G. Cohen, G. Mikhalkin, H. Rullgard, I. Mundet i Riera, I. Simon, I. M. Gel’fand, J. Richter-Gebert, J.-E. Pin, J.-P. Demailly, J. M. Baptista, K. Cieliebak, K. Cieliebak, Kazutoshi Ohta, L. I. Ronkin, M. Arai, M. Klimek, M. Naganuma, Masahito Yamazaki, Muneto Nitta, Norisuke Sakai, R. Kenyon, Toshiaki Fujimori   +25 more
core   +1 more source

Consistent Choice of Prey Source Habitat Across Diverse Landscapes by a Selective Insectivorous Bat

Integrative Zoology, EarlyView.
After analyzing the diet of the greater horseshoe bats in three distinct colonies, we identified significant spatial and temporal differences, particularly noting a stronger reliance on riparian habitats in Mediterranean areas. The species exhibits great ecological adaptability with strong plasticity in prey source habitats, shifting preferences among ...
Miren Aldasoro, Oihane Diaz de Cerio, Danilo Russo, Nerea Vallejo, Lander Olasagasti, Inazio Garin, Urtzi Goiti, Joxerra Aihartza   +7 more
wiley   +1 more source

Stochastic Database Cracking: Towards Robust Adaptive Indexing in Main-Memory Column-Stores [PDF]

, 2012
Modern business applications and scientific databases call for inherently dynamic data storage environments. Such environments are characterized by two challenging features: (a) they have little idle system time to devote on physical design; and (b ...
Halim, Felix, Idreos, Stratos, Karras, Panagiotis, Yap, Roland H. C.   +3 more
core   +1 more source

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles (Lasiopodomys brandtii): Behavioral and Transcriptomic Insights

Integrative Zoology, EarlyView.
Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li, Congcong Qiao, Xiujuan Li, Maolin Huang, Zhenlong Wang, Luye Shi   +5 more
wiley   +1 more source

Sanctions, National Security, and Free Speech

Global Policy, EarlyView.
ABSTRACT A fundamental, but largely overlooked, aspect of the New Washington Consensus is the use of national security arguments to restrict speech and punish disfavored speakers. Although the United States has a longer history of using sanctions to restrict speech in the terrorism context, it has recently applied sanctions to restrict political speech,
Joshua Andresen
wiley   +1 more source

Flexible and accurate inference and learning for deep generative models [PDF]

, 2018
We introduce a new approach to learning in hierarchical latent-variable generative models called the "distributed distributional code Helmholtz machine", which emphasises flexibility and accuracy in the inferential process.
Sahani, Maneesh, Vertes, Eszter
core   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source