Results 31 to 40 of about 64,857 (161)
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Geophysical Monograph Series, Page i-xiv., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
wiley +1 more source
The Antitrust of Reputation Mechanisms: Institutional Economics and Concerted Refusals to Deal [PDF]
, 2009 An agreement among competitors to refuse to deal with another party is traditionally per se illegal under the antitrust laws. But coordinated refusals to deal are often necessary to punish wrongdoers, and thus to deter undesirable behavior that state ...
Richman, Barak D.
core +1 more source
Growing Degree‐Day Trends Associated With ‘False Springs’ in the Continental United States
International Journal of Climatology, EarlyView.Earlier spring warming has increased growing degree‐day (GDD) accumulation prior to the last freeze at some US locations (red circles = stat. sig. increases). However, after accounting for spatial autocorrelation using a false discovery rate approach, few trends remain significant, indicating no coherent continental‐scale increase in false spring risk.
Robert E. Davis +3 more
wiley +1 more source
HILT : High-Level Thesaurus Project. Phase IV and Embedding Project Extension : Final Report [PDF]
, 2009 Ensuring that Higher Education (HE) and Further Education (FE) users of the JISC IE can find appropriate learning, research and information resources by subject search and browse in an environment where most national and institutional service providers -
Joseph, Anu +2 more
core
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Small, EarlyView.Electron nanodiffraction mapping was used to determine that the 3D leg configuration of branched plasmonic AuAg nanostars is associated with the icosahedral symmetry of the star core, providing a deeper understanding of their growth mechanism and thus paving the way to the development of optimized synthesis protocols targeting optical enhancement ...
Leonardo M. Corrêa +7 more
wiley +1 more source
Advances in the Different Synthetic Routes of Fluorinated Hydrazines
The Chemical Record, EarlyView.This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley +1 more source