Results 61 to 70 of about 74,286 (216)

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles (Lasiopodomys brandtii): Behavioral and Transcriptomic Insights

Integrative Zoology, EarlyView.
Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li, Congcong Qiao, Xiujuan Li, Maolin Huang, Zhenlong Wang, Luye Shi   +5 more
wiley   +1 more source

Sanctions, National Security, and Free Speech

Global Policy, EarlyView.
ABSTRACT A fundamental, but largely overlooked, aspect of the New Washington Consensus is the use of national security arguments to restrict speech and punish disfavored speakers. Although the United States has a longer history of using sanctions to restrict speech in the terrorism context, it has recently applied sanctions to restrict political speech,
Joshua Andresen
wiley   +1 more source

Stochastic Database Cracking: Towards Robust Adaptive Indexing in Main-Memory Column-Stores [PDF]

, 2012
Modern business applications and scientific databases call for inherently dynamic data storage environments. Such environments are characterized by two challenging features: (a) they have little idle system time to devote on physical design; and (b ...
Halim, Felix, Idreos, Stratos, Karras, Panagiotis, Yap, Roland H. C.   +3 more
core   +1 more source

A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system

BMC Biotechnology, 2004
BackgroundWhether for cell culture studies of protein function, construction of mouse models to enable in vivo analysis of disease epidemiology, or ultimately gene therapy of human diseases, a critical enabling step is the ability to achieve finely ...
Marina Sudomoina, Ekaterina Latypova, O. O. Favorova, E. Golemis, I. Serebriiskii   +4 more
semanticscholar   +1 more source

Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2‐Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open‐Label, Single‐Arm, Phase IV Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
A phase IV, single‐arm, open‐label, multicenter study assessing the safety and efficacy of trastuzumab emtansine in Indian patients for the treatment of human epidermal growth factor receptor 2 (HER2)‐positive unresectable locally advanced or metastatic breast cancer who received prior treatment with trastuzumab and a taxane.
Sudeep Gupta, Manish Singhal, Shona Nag, Waseem Abbas, Dinesh Chandra Doval, Hari Goyal, Chirag Shah, Ashish Singh, Radheshyam Naik, Nitesh Rohatgi, Poonam Patil, Shyam Aggarwal, Vinod Raina, Vaibhav Watts   +13 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

DDC Lesson Plan [PDF]

, 2023
This lesson is designed as a one-shot lecture to teach first-year library students how to classify under the Dewey Decimal Classification system. It is designed for students with little to no prior knowledge of the DDC, but can also serve as a useful refresher for those with prior knowledge.
openaire  

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Characterization of Vesicular Monoamine Transporter 2 and its role in Parkinson\u27s Disease Pathogenesis using Drosophila [PDF]

, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain.
Tito, Antonio Joel, Jr., Zhang, Sheng
core   +1 more source

Global Citizenship in Clinical Training: A Qualitative Study Evaluating a Co‐Creation Approach to Community Oral Health Interventions

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction Oral health plays a crucial role in overall well‐being, impacting general health, psychological health and quality of life. Vulnerable groups often face higher rates of oral health problems, exacerbating inequalities. This study evaluates the effectiveness of student‐delivered oral health interventions with these groups using a co‐
Mahdi Hussaini, Andrea Rodriguez, Clement Seeballuck   +2 more
wiley   +1 more source