Results 21 to 30 of about 94,100 (113)

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, M. Köll-Weber, R. Süss
semanticscholar   +1 more source

lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p

BioMed Research International, 2021
Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development.
Yi Wang, Ming Ding, Xiaoqing Yuan, Ruibao Jiao, Dagao Zhu, Wanzhong Huang, Wenxia Deng, Yulong Liu   +7 more
semanticscholar   +1 more source

Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis

Journal of Biomedical Sciences, 2020
Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrovascular disease.
Shanchao Zhang, G. Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu, Aihua Wang   +8 more
semanticscholar   +1 more source

Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma

Molecular Cancer, 2020
Circular RNAs (circRNAs) have been reported to have critical regulatory roles in tumor biology. However, their contribution to melanoma remains largely unknown.
Chuanyuan Wei, Mengxuan Zhu, Nanhang Lu, Jia-qi Liu, Yanwen Yang, Yong Zhang, Yue-dong Shi, Zi-hao Feng, Jia-Xia li, F. Qi, Jian-Ying Gu   +10 more
semanticscholar   +1 more source

Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2.

Biological Psychiatry, 2019
BACKGROUND Many polymorphisms in dopamine genes are reported to affect cognitive, imaging, or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the polymorphism on the gene product ...
E. Tunbridge, Marco Narajos, C. Harrison, Charles Beresford, Paul J. Harrison   +4 more
semanticscholar   +1 more source

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Scientific Reports, 2020
Bradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart failure
J. Yanni, A. D’Souza, Yanwen Wang, Ning Li, Brian J. Hansen, S. Zakharkin, Matthew Smith, C. Hayward, B. Whitson, P. Mohler, P. Janssen, L. Zeef, M. Choudhury, M. Zi, Xue Cai, S. Logantha, S. Nakao, A. Atkinson, M. Petkova, Ursula Doris, J. Ariyaratnam, E. Cartwright, S. Griffiths-Jones, G. Hart, V. Fedorov, D. Oceandy, H. Dobrzynski, M. Boyett   +27 more
semanticscholar   +1 more source

LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B cell lymphoma.

Carcinogenesis, 2021
Diffuse large B-cell lymphoma (DLBCL) remains to be a high aggressive and invasive malignancy with enigmatic etiology. Ectopic expression of long noncoding RNAs are widely involved in the progression of human cancers.
Y. Huang, Yuanyuan Lin, Xiangxiang Song, Depei Wu   +3 more
semanticscholar   +1 more source

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

Acta Neuropathologica
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge, B. Lehallier, Pardis Zarifkar, P. M. Losada, M. Shahid-Besanti, D. Western, P. Gorijala, S. Ryman, M. Yutsis, Gayle K. Deutsch, Elizabeth C. Mormino, A. Trelle, Anthony D. Wagner, Geoffrey A. Kerchner, Lu Tian, C. Cruchaga, V. Henderson, T. Montine, P. Borghammer, T. Wyss‐Coray, K. Poston   +20 more
semanticscholar   +1 more source

Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

Molecular Therapy: Nucleic Acids, 2019
Circular RNA (circRNA) is a novel subgroup of noncoding RNA in the human transcriptome playing a vital role in the atherosclerosis of cerebrovascular disease.
Lei Yang, Fan Yang, Haikang Zhao, Maode Wang, Yuelin Zhang   +4 more
semanticscholar   +1 more source

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

International Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki, Maria Papatsirou, Michaela A. Boti, P. Adamopoulos, S. Christodoulou, D. Vassilacopoulou, A. Scorilas, C. Kontos   +7 more
semanticscholar   +1 more source