Results 11 to 20 of about 2,076 (67)

An Efficient CO₂-Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate-Utilizing Capacity via Adaptive Laboratory Evolution. [PDF]

Adv Sci (Weinh)
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Wang C, Chen TT, Yang YJ, Li YX, Chang YX, Xiao YC, Guo WT, Zheng Y, Deng RZ, Tian YX, Situ W, Shen HW, Chen Y, Wang YB, Xing J, Wang H, Xia L, Lin YN, Ye JW.   +18 more
europepmc   +2 more sources

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Interactions Between O‐Phospho‐L‐Serine and Trivalent Metal Ions: Studies in Solution and Solid State

European Journal of Inorganic Chemistry, EarlyView.
The interaction between the phosphorylated amino acid O‐phospho‐L‐serine and trivalent ions of f‐elements such as La3+, Eu3+, and Lu3+, supplemented by Y3+, has been studied in aqueous media. Nuclear magnetic resonance (NMR) spectroscopy in solution and in the solid state examined complex formation from the ligand perspective, while time‐resolved laser‐
Jonas Kunigkeit, Björn Drobot, Dominik Goldbach, Silvia Paasch, Gudrun Scholz, Thorsten Stumpf, Eike Brunner, Jerome Kretzschmar   +7 more
wiley   +1 more source

MRI‐based qualitative, quantitative, and radiomics/deep learning methods for assessing treatment response after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Precision Radiation Oncology, EarlyView.
MRI, owing to its superior soft tissue contrast and spatial resolution, has become the preferred noninvasive modality for assessing nCRT efficacy. This review synthesizes current evidence on MRI‐based assessment of nCRT efficacy in LARC and discusses future directions.
Shuang Chen, Lin Liu, Guangwei Tian, Ruimei Chai   +3 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Isolation, RP‐UHPLC‐ESI‐LIT‐Orbitrap‐MS/MS‐Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae)

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
This paper describes the isolation and antifungal activity of secondary metabolites from the leaves and roots of Monotes kerstingii. The distribution of these metabolites in the roots and leaves was achieved through comprehensive RP‐UHPLC‐Orbitrap‐MS and MS/MS analysis.
Sorelle Kache Fotsing, Dominique Ngnintedo, Yanick Kevin Dongmo Melogmo, Alena Soboleva, Kevine Dongmo Jumeta, Bruno Ndjakou Lenta, Fabrice Fekam Boyom, Andrej Frolov, Norbert Arnold, Ludger A. Wessjohann, Norbert Sewald, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso   +12 more
wiley   +1 more source

Allelopathy as a Strategy for Biological Invasion: Calotropis procera and Its Impact on Plant Succession

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Stages of the study on the allelopathic potential of Calotropis procera (Aiton) W. T. Aiton. The image shows the collection of plant material, the decomposition of organic matter, the identification of bioactive compounds, and the effects on the germination of Handroanthus impetiginosus (Mart. ex DC.) Mattos.
Bruno Melo de Alcântara, Paulo Henrique Calixto Santana, Felipe Rufino dos Santos, José Weverton Almeida‐Bezerra, José Galberto Martins da Costa, Delmira da Costa Silva, Cláudia Maria Furlan, Maria Arlene Pessoa da Silva   +7 more
wiley   +1 more source

An Ecological Definition and Objective Threshold for Differentiating Small Fragments

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Many ecological phenomena vary with fragment size. To quantify the impacts of small fragments on ecological pattern and process, one must differentiate them, but there is no agreed way to achieve this. We present an objective definition and method to identify a threshold size for small fragments that requires minimal data and can be readily calculated ...
David C. Deane, Cang Hui, Melodie McGeoch   +2 more
wiley   +1 more source

Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Replication cycle of HIV‐1. The scheme provides an overview from virus entry over reverse transcription of viral RNA into viral DNA, provirus DNA integration into the host genome, genome expression by transcription and translation, proteolytic processing of the viral polyproteins, viral maturation to viral release from the cell. The various targets for
Harald Brüssow
wiley   +1 more source

Quantifying the Hydrological Niche of Upland Swamp Plant Communities Using Indicator Species

Ecohydrology, Volume 19, Issue 1, January‐February 2026.
ABSTRACT Coastal Upland Swamps of the Sydney Basin Bioregion, Australia, are highly biodiverse upland mires. Swamp vegetation organises into five communities, thought to occupy distinct positions along a hydrological gradient. Longwall mining reduces the duration of root zone saturation, but lack of quantitative understanding of hydrological niche ...
David C. Deane, Tanya J. Mason, Joe Cairns, Martin Krogh, David A. Keith   +4 more
wiley   +1 more source