Suppressor of gamma response 1 modulates the DNA damage response and oxidative stress response in leaves of cadmium-exposed Arabidopsis thaliana [PDF]
, 2020 Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR).
Cuypers, Ann +9 more
core +1 more source
DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W +10 more
core +1 more source
Therapeutic Targeting of DNA Damage Repair in the Era of Precision Oncology and Immune Checkpoint Inhibitors [PDF]
Journal of Immunotherapy and Precision Oncology, 2023 Cancer manifestation is a multistep process involving accumulation of various genetic and epigenetic changes that results in oncogenic “hallmarks of cancer” processes including genomic instability.
Curtis A. Clark, Eddy S. Yang
doaj +1 more source
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas [PDF]
, 2018 DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Alvaro, Domenico +41 more
core +4 more sources
Alternatif Politika, 2023 DDR processes, the design of which follows technical knowledge produced by international organizations and programs, have become a standard way for addressing the process of armed groups’ transition from armed to civilian life. However, the components of
Esra Dilek, Başar Baysal
doaj +1 more source
The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]
, 2018 Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren +4 more
core +1 more source
Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX [PDF]
, 2018 Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX ...
Gbolahan, Olumide +8 more
core +1 more source
Jurnal Anestesi Perioperatif, 2021 Nyeri pascaoperasi harus diatasi dengan baik. Berbagai metode analgetik dilakukan untuk mengatasi nyeri pascaoperasi kolesistektomi laparoskopik, namun tidak ada yang ideal dalam menangani nyeri pascaoperasi.
Arrys Prabowo +2 more
doaj +1 more source
Comment on the Dependence of R□ and Current Noise on Grain Size in Thick Film Resistors (TFR's)
Active and Passive Electronic Components, 1985 The heterogeneous structure of TFR's results in high resistivities and high current noise. Accepting models of conduction in TFR's, according to which the resistivity is determined by a resistance independent of bulk-resistivity of a metallic-like ...
M. Wolf, F. Müller, H. Hemschik
doaj +1 more source
Ciudad Paz-ando, 2022 El propósito de este artículo es indagar sobre las investigaciones que se han hecho respecto a la educación para excombatientes a nivel nacional e internacional. Se hallaron tres grandes tendencias: 1.
Rober Fernando Buitrago Castellanos
doaj +1 more source