Results 161 to 170 of about 190,243 (246)

An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Tuvusertib is an investigational, orally administered inhibitor of ATR protein kinase, currently in Phase II clinical development. Here, we present an integrated nonclinical and clinical assessment of the effect of tuvusertib on QTc interval.
Jatinder Kaur Mukker, Timothy A. Yap, Anthony W. Tolcher, Johann S. de Bono, Ruth Plummer, Gary Grosser, Christoph van Amsterdam, Hanno Schieferstein, Han Witjes, Paul Matthias Diderichsen, Axel Krebs‐Brown, Wei Gao, Rainer Strotmann, Zoltan Szucs, Ioannis Gounaris, Karthik Venkatakrishnan   +15 more
wiley   +1 more source

Two-stage deep learning approach for screening for anterior disk displacement of the temporomandibular joint using orthopantomograms. [PDF]

Sci Rep
Kim JS, Kim T, Ahn YH, Kim HG, Ahn SJ.
europepmc   +1 more source

The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition. [PDF]

Front Cell Dev Biol
Giuntini F, Whitfield JR, Massó-Vallés D, Soucek L.   +3 more
europepmc   +1 more source

Mutational landscape and risk estimates of DDR genes in Chinese ovarian cancer patients. [PDF]

J Ovarian Res
Zhang C, Wei B, Xue X, Xia Q, Wang Y, Guo L, Wang T, Wang L, Deng J, Guan Y, Wang X, Feng L, Wu R, Hu Z, Kok K, van den Berg A, Guo Y, Li J.   +17 more
europepmc   +1 more source

Impact of Germline DNA Repair Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Development. [PDF]

Curr Hematol Malig Rep
Fedorov K, Luo LY, Bick AG, Savona MR.
europepmc   +1 more source

CHEK2 loss endows chemotherapy resistance to hematopoietic stem cells. [PDF]

Leukemia
Zhou J, Hu T, Li D, Li S, Li M, Shi X, Nakada D.   +6 more
europepmc   +1 more source

Implications of DNA damage response and immunotherapy in tumor therapy. [PDF]

Cell Commun Signal
Li W, Li B, Cai C, Chen J, Li Y, Liang R, Zhao J.   +6 more
europepmc   +1 more source

Targeting DNA Damage Response and Immune Crosstalk in Cancer: Mechanistic Insights and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Marcut L, Brata RD, Barb AC, Manole A, Stef DG, Dumitru CS, Zara F, Patrascu R.   +7 more
europepmc   +1 more source

DDR-Lesefutter

Das mediale Erbe der DDR, 2022
openaire   +1 more source

The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair. [PDF]

Cell Death Discov
Giovannini S, Fiorilli C, Moriconi V, Shi Y, Candi E, Melino G, Bernassola F.   +6 more
europepmc   +1 more source