Results 141 to 150 of about 66,929 (277)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, Volume 16, Issue 7, Page 1305-1313, July 2026.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Nach Vilsmeier formylierte Thioäther und Umsetzung der Reaktionsprodukte zu Polymethinfarbstoffen

CHIMIA, 1966
Bodo Hirsch, Eckhart Förster
doaj   +1 more source

Duocarmycin‐Bearing Antibody‐Mimetic Drug Conjugate Combined With an ATR Inhibitor Results in Complete Tumor Regression in a KPL‐4 Xenograft Model

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Antibody–drug conjugates (ADCs) have demonstrated superior clinical outcomes in patients with HER2‐positive advanced breast cancer compared with previous treatment modalities. However, resistance and treatment‐limiting toxicities frequently emerge during repeated administration, underscoring an unmet need for strategies to overcome ADC failure.
Toshiya Tanaka, Akira Sugiyama, Juri Sakata, Toshifumi Tatsumi, Hiroto Katoh, Keisuke Maeda, Yuya Inagaki, Takefumi Yamashita, Takeshi Kawamura, Mayu Kuratani, Taiki Nakano, Masazumi Ishii, Mai Miura, Wakana Kamiya, Yuko Shiratori, Hisato Kitanoya, Michael Chansler, Naoki Harada, Masayuki Tsuchiya, Tsuyoshi Osawa, Shumpei Ishikawa, Tatsuhiko Kodama, Kenzo Yamatsugu, Hidetoshi Tokuyama, Motomu Kanai   +24 more
wiley   +1 more source

Inverse sky islands: lowland river valleys drive microbial divergence while high elevations select for convergence in massive mountain ecosystems

Ecography, Volume 2026, Issue 7, July 2026.
Mountain ecosystems are often interpreted through the lens of the ‘sky island' model, where high‐elevation habitats function as isolated archipelagos. However, this model's applicability to massive, topographically complex mountain ranges where highlands are continuous and lowlands are fragmented remains untested.
Yazhou Zhang, J. Aaron Hogan, Jianjun Wang, Wenguang Sun, Yaojun Ye, Xin Liu, Minshu Song, Hang Sun   +7 more
wiley   +1 more source

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li, Binfan He, Mengmeng Hao, Ye Liu, Shunxin Song, Rongzhang He   +5 more
wiley   +1 more source

England's Dementia Diagnosis Landscape: Strengths, Limitations, and Future Directions

International Journal of Geriatric Psychiatry, Volume 41, Issue 7, July 2026.
ABSTRACT Background The National Health Service (NHS) England Primary Care Dementia Data (PCDD) provides a comprehensive dementia registry, underpinning national policy to improve diagnosis, care, and support. Methods This paper evaluates the PCDD in comparison with international quality dementia registries (SveDem, NorCog, ADNeT). Results We highlight
Jemma Hazan, Robert Howard, Jeremy D. Isaacs   +2 more
wiley   +1 more source

Neues Verfahren zur Darstellung α-substituierter Pyrazolon-(5)-trimethin-oxonole

CHIMIA, 1970
Bodo Hirsch, Eckhart Förster
doaj   +1 more source

From Germline Susceptibility to Therapeutic Vulnerability: DNA Damage Response Gene Mutations Driving Multiple Myeloma Evolution and Precision Therapy. [PDF]

Hum Mutat
Shen Q, Wang Y, Cai L, Qian J.
europepmc   +1 more source

Integrative Transcriptomic and Functional Analysis of PKMYT1 Reveals a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

Hematological Oncology, Volume 44, Issue 4, July 2026.
ABSTRACT Chronic lymphocytic leukemia (CLL) is a clinically and molecularly heterogeneous disease. PKMYT1, a G2/M cell cycle kinase, has been implicated in tumor progression in several cancers, but its role in CLL remains unclear. We evaluated PKMYT1 expression in primary CLL samples and analyzed associations with cytogenetic features and clinical ...
Elizabete Cristina Iseke Bispo, Cláudia de Souza Lima Pontes, Jennifer Martins do Nascimento, Fábio Wilson de Lima Alves, Juliana Lott de Carvalho, Antônio Roberto Lucena‐Araujo, Felipe Saldanha‐Araujo   +6 more
wiley   +1 more source