Results 141 to 150 of about 32,248 (253)

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

Aging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan   +11 more
wiley   +1 more source

Diversity of Factors Associated with Physical Inactivity in Patients with Asthma Based on Activity Intensity. [PDF]

J Clin Med
Murakawa K, Hirano T, Doi K, Fukatsu-Chikumoto A, Yamaji Y, Iwamoto H, Miyamoto S, Higaki N, Amano Y, Anabuki K, Yamane M, Oishi K, Asami-Noyama M, Edakuni N, Kakugawa T, Matsunaga K.   +15 more
europepmc   +1 more source

ZIP1 Is a Critical DNA Damage‐Responsive Zinc Transporter Induced by Bleomycin via the TNFα–NF‐κB Pathway

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
The zinc transporter ZIP1 is induced promptly following treatment with the DNA damage agent bleomycin through the TNFα–NF‐κB pathway. NF‐κB accumulates in the nucleus and upregulates the transcription of SLC39A1, the coding gene for ZIP1. The increased expression of ZIP1 leads to elevated intracellular zinc levels, which, in turn, enhance the DNA ...
Zichong Li, Jiajian Yuan, Ziqi Zhang, Hong Huang, Mei Hong   +4 more
wiley   +1 more source

Accurate prediction of candidate lncRNAs associated with DNA damage response based on gene expression patterns from graph neural networks. [PDF]

Bioinform Adv
Shah S, Wang L.
europepmc   +1 more source

Relationship between bisphosphonate use and risks of recurrence and mortality among hormone receptor–positive and triple‐negative breast cancer patients

Cancer, Volume 132, Issue 16, 15 August 2026.
Abstract Background Bisphosphonates (BPs) are routinely used as an adjuvant therapy for breast cancer to reduce the risk of bone recurrences given their anti‐resorptive effects on bones and antitumor characteristics. However, there remains limited evidence regarding their utility across different subtypes. Methods In this population‐based cohort study,
Liuye Huang, Linda S. Cook, Mei‐Tzu C. Tang, David R. Doody, Ulrike Peters, Wei Sun, Jeroen R. Huyghe, Kathleen E. Malone, Christopher I. Li   +8 more
wiley   +1 more source

Reconstructing EBV reactivation and DNA damage response kinetics in morphologic pseudotime. [PDF]

Proc Natl Acad Sci U S A
Tekle DG, Dobry CJ, Sexton JZ, SoRelle ED.   +3 more
europepmc   +1 more source

England's Dementia Diagnosis Landscape: Strengths, Limitations, and Future Directions. [PDF]

Int J Geriatr Psychiatry
Hazan J, Howard R, Isaacs JD.
europepmc   +1 more source

DDR-Lesefutter

Das mediale Erbe der DDR, 2022
openaire   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, Volume 13, Issue 43, 3 August 2026.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Radiogenomics and the DNA damage response: opportunities for biomarker-guided radiosensitization in pancreatic cancer. [PDF]

Front Oncol
Karam MN, Hajj J, Crane CH, Ramia P, Geara F, Hamadeh N, Scott JG, Grobmyer S, Almond R, O'Reilly EM, Hajj C.   +10 more
europepmc   +1 more source