Results 161 to 170 of about 32,248 (253)

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao   +4 more
wiley   +1 more source

Early‐Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection

open access: yesMedComm, Volume 7, Issue 8, August 2026.
EOPC is a distinct clinicopathological entity separable from SOPC, differing fundamentally in genetic susceptibility, TMPRSS2:ERG fusion frequency, and survival outcomes. Although research remains nascent, this review provides the first comprehensive synthesis of current evidence, offering a critical foundation to guide future investigations into this ...
Xingyu Xiong   +8 more
wiley   +1 more source

Respiratory Models Reveal DNA Damage Response Modulation by Merkel Cell Polyomavirus. [PDF]

open access: yesInt J Mol Sci
Passerini S   +7 more
europepmc   +1 more source

A Comparative dose and image quality assessment of a portable, multi‐modality extremity imaging system for austere environments

open access: yesMedical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Rapid technological innovation in diagnostic imaging requires timely, evidence‐based safety and quality assessment to ensure optimal patient care. This study evaluates a novel multi‐modality extremity imaging system (OXOS MC2) designed for deployment in remote and austere environments.
Xiangyu Yang   +6 more
wiley   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

open access: yesSmall, Volume 22, Issue 45, 13 August 2026.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji   +13 more
wiley   +1 more source

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