Results 121 to 130 of about 208,136 (294)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Azapolymethinfarbstoffe durch nucleophile Substitution am Stickstoff

CHIMIA, 1966
B. Hirsch, E.-A. Jauer, B.N. Baijal
doaj   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, EarlyView.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Über die drucklose Hydrierung von 3-Cyanpyridin

CHIMIA, 1969
Eberhard Fischer, Gerhard Rembarz, Peter Franke   +2 more
doaj   +1 more source

Aufarbeitung der DDR-Psychotherapie als transdisziplinäres Forschungsfeld [PDF]

, 2022
Adrian Gallistl, Harriet Kirschner, Gordana Paripovic, Manuel Rauschenbach, Monika Storch, Bernhard Strauß   +5 more
openalex   +1 more source

Effect of the Buccal Gap Width on Alveolar Process Reduction Following Immediate Implant Placement: A Retrospective CBCT Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To evaluate the effect of the width of the buccal gap on the alveolar process reduction after immediate implant placement (IIP) at maxillary central incisor sites, compared to contralateral pristine tooth sites. Material and Methods Twenty‐eight subjects who were treated with IIP to replace a maxillary central incisor and presented ...
Maurício G. Araújo, Debora R. Dias, Ping Wang, Robert A. Levine   +3 more
wiley   +1 more source

Cellular Morphometric Analysis (CellMorph)—a comprehensive imaging‐based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes

The FEBS Journal, EarlyView.
CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira, Solon Andrades da Rosa, Luiza Cherobini Pereira, Laura Boose de Mendonça, Juliete Scholl, Fabrício Figueiró, Thais Cardoso Bitencourt, Davi Piovesan Echevarria, João Luiz Aldinucci Buzzo, Jessica Boschini D'Agostin, Danieli Rosane Dallemole, Carolina Oliveira, Fernanda Simas, Fernanda Saez‐Calazans, Débora Santos‐Sousa, Guido Lenz, Eduardo C. Filippi‐Chiela   +16 more
wiley   +1 more source

Die Tautomerie des 1,2,4-Triazols

CHIMIA, 1967
Carl-Friedrich Kröger, Walter Freiberg
doaj   +1 more source

Advancing Computational Thinking in Mathematics Education: a Systematic Review of Indonesian Research Landscape

JTAM (Jurnal Teori dan Aplikasi Matematika)
Computational Thinking (CT) has emerged as a crucial and foundational skill in the 21st century, capturing the attention of researchers across various domains, including mathematics education in Indonesia.
Edi Irawan, Rizky Rosjanuardi, Sufyani Prabawanto   +2 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source