Results 101 to 110 of about 32,248 (253)

DDR

, 2022
  +4 more sources

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Anwendung der Hammett-Gleichung auf die Acidität von 3-Brom-1,2,4-triazolen

CHIMIA, 1967
Walter Freiberg, Carl-Friedrich Kröger
doaj   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Zur Mikroanalytik phenolischer Hydroxy- und Hydroxycarbonylverbindungen

CHIMIA, 1966
Wolfgang Wildenhain, Günter Henseke
doaj   +1 more source

Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du, Shunsuke Koga, Guang Yang, Saar Gill, Adam Bagg   +4 more
wiley   +1 more source

Nach Vilsmeier formylierte Thioäther und Umsetzung der Reaktionsprodukte zu Polymethinfarbstoffen

CHIMIA, 1966
Bodo Hirsch, Eckhart Förster
doaj   +1 more source

Methodological Quality of Prognostic Models for Periodontitis: A Systematic Review and Critical Appraisal

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To critically appraise the methodological quality and historical evolution of prognostic models for periodontitis. Materials and Methods A systematic search was conducted in three databases. Eligible studies were classified as conceptual tools, category‐based tools and data‐driven models.
Maryia Karaban, Debora R. Dias, Giuseppe Troiano, Sahar Baniameri, Ishan Ahuja, Divya Joseph, Matteo Serroni, Andrea Ravidà   +7 more
wiley   +1 more source

‘The Guilt Complex’: Assessing How Perceptions of Guilt Impact Reintegration Experiences of Young Returnees from the FARC Across Colombia

Journal for Deradicalization
This paper examines the first-hand narratives of young people who were former combatants of the FARC-EP (Fuerzas Armadas Revolucionarias de Colombia-Ejército del Pueblo) in Colombia and demobilised after signing the 2016 Peace Agreement.
Arpita Mitra, Joris van Wijk, Elanie Rodermond   +2 more
doaj