Results 101 to 110 of about 66,929 (277)
MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Cancer Science, EarlyView.Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
wiley +1 more source
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
Rechnernetzforschung und –entwicklung an der TU Dresden [PDF]
, 2008 Seit Beginn der siebziger Jahre war die TU Dresden ein Zentrum der Rechnernetzforschung in der DDR. Die entsprechenden Arbeiten konzentrierten sich auf Grundlagenforschung, auf die Mitwirkung am Aufbau und der Nutzung des Rechnernetzes DELTA sowie auf ...
Löffler, Helmut
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Cancer Science, EarlyView.Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara +21 more
wiley +1 more source
Von den Anfängen der objektorientierten Softwareentwicklung an der TU Ilmenau bis zu einem Ansatz für ein komponentenorientiertes Softwaresystem [PDF]
, 2008 In der Arbeit wird kurz die Geschichte der objektorientierten Softwareentwicklung an der TH Ilmenau aufgezeigt, um dann auf die durch Kompositionsabstraktion erreichten Eigenschaften eines Objektes einzugehen.
Schönefeld, Reinhold
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Cell Proliferation, EarlyView.CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh +4 more
wiley +1 more source
, 2020 Man kennt sie nicht, man sieht sie nicht, man liest nichts über sie. Nur selten spielen DDR-Künstler im Diskurs eine Rolle und wenn, dann werden sie auf bekannte Narrative reduziert. Sogar von den eigenen Kollegen.
Bianca Kellner-Zotz
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The FEBS Journal, EarlyView.CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira +16 more
wiley +1 more source
Disarmament, Demobilization, and Reintegration: The co-evolution of concepts, practices, and understanding [PDF]
, 2009 Programs for the Disarmament, Demobilization, and Reintegration (DDR) of ex-combatants have become more common as an element in the peacebuilder’s toolkit.
Kilroy, Walt
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Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source