Results 81 to 90 of about 32,248 (253)

Ranavirus risk depends on host community characteristics more than the presence of Batrachochytrium dendrobatidis

open access: yesOikos, EarlyView.
Novel parasite introductions are threatening wildlife communities globally. The degree of threat depends on the ecological context, namely host community characteristics and the presence of other parasites. How these two factors interact to shape the outcomes of parasite introductions is not known. We experimentally investigated how infection following
David R. Daversa   +5 more
wiley   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

open access: yesThe Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi   +8 more
wiley   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

open access: yesPrecision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu   +4 more
wiley   +1 more source

Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer

open access: yesPrecision Radiation Oncology, EarlyView.
The study showed that TOMO‐mediated RIBE is activated by decreasing exosomal hnRNPA1 protein level and its capability to packaging miR‐27a‐3p. These new findings infer that hnRNPA1 is a novel inhibitor of RIBE, which potentiates to be a new therapeutic target for improving the efficacy of radiotherapy.
Meng‐Qi Yang   +11 more
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao   +3 more
wiley   +1 more source

Über die drucklose Hydrierung von 3-Cyanpyridin

open access: yesCHIMIA, 1969
Eberhard Fischer   +2 more
doaj   +1 more source

Bird extinctions shift bill–flower trait matching in Hawaiian lobelioids

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Species extinctions can reorganize ecological interactions by altering the distribution of functional traits within communities. These traits structure how species interact, influencing whether encounters result in mutualistic or antagonistic outcomes.
Samuel B. Case   +6 more
wiley   +1 more source

The Not‐So‐Neue Frau: Weimar Berlin's Modern Women and Generational Identity After 1945

open access: yesGender &History, EarlyView.
ABSTRACT This article studies the post‐1945 literary careers of Gabriele Tergit and Ilse Langner, two ageing German writers. Both had enjoyed promising careers as young women in Weimar Berlin, but Nazism and war disrupted their professional trajectories in varying ways. After 1945, they tried and failed to recapture their Weimar‐era success, eventually
Katharina Friege
wiley   +1 more source

Die wissenschaftlichen Bibliotheken der DDR nach der Wiedervereinigung

open access: yesBibliothek
Die Transformation der wissenschaftlichen Bibliotheken der DDR nach der Wiedervereinigung führte zu einer Modernisierung von Strukturen, Bestand und Technolgie sowie zu einer personellen Erneuerung.
Knoche Michael
doaj   +1 more source

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