Results 81 to 90 of about 208,136 (294)
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
IET Cyber-Physical Systems, 2019 This study proposes a novel user-centric cyber-physical framework to achieve distributed demand response (DDR) in a distribution system where local schedulers (LS) present at individual buses program both local and non-local loads to reduce the maximum ...
Swaroop Ranjan Mishra +3 more
doaj +1 more source
Trust and glycemic control in black patients with diabetic retinopathy: A pilot study [PDF]
, 2019 Diabetic retinopathy (DR) is more prevalent in blacks than whites because, compared to whites, blacks on average have worse glycemic control. Both of these racial disparities reflect differences in sociocultural determinants of health, including ...
Casten, Robin J., Rovner, Barry W.
core +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
Derivative Dispersion Relations
, 2004 We discuss some analytical and numerical aspects related to the replacement of integral dispersion relations by derivative relations and also the practical applicability of the derivative approach in the investigation of high-energy elastic hadron-hadron
Avila, R. F., Menon, M. J.
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller +16 more
wiley +1 more source
Regional gene repression by DNA double-strand breaks in G1 phase cells [PDF]
, 2019 DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for ...
Collins, Patrick L +6 more
core +2 more sources
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
172MO Analysis of comutations in DNA damage repair (DDR) related pathways with immunotherapeutic biomarkers in Chinese lung cancer patients [PDF]
, 2022 Jianwei Li +4 more
openalex +1 more source
International Journal of Cancer, EarlyView.What's New? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte +10 more
wiley +1 more source