Results 61 to 70 of about 208,136 (294)

Fluid Dynamical Profiles and Constants of Motion from d-Branes [PDF]

, 1999
Various fluid mechanical systems enjoy a hidden, higher-dimensional dynamical Poincare symmetry, which arises owing to their descent from a Nambu-Goto action.
Jackiw, R., Polychronakos, A. P.
core   +4 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Implementing DDR in Settings of Ongoing Conflict: The Organization and Fragmentation of Armed Groups in the Democratic Republic of Congo (DRC)

Stability : International Journal of Security and Development, 2016
Although it is common for armed groups to splinter (or “fragment”) during contexts of multi-party civil war, current guidance on Disarmament, Demobilization, and Reintegration (DDR) does not address the challenges that arise when recalcitrant fighters ...
Joanne Richards
doaj   +1 more source

Therapeutic opportunities within the DNA damage response [PDF]

, 2015
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the cell, and its disruption is one of the hallmarks of cancer.
A Chatr-Aryamontri, A Franceschini, A Franchitto, A Gaulton, AA Larrea, AC Antoniou, AE Tomkinson, AJ Bardin, AK Rustgi, AL Chambers, AL Marston, Amanda C. Schierz, AP Eker, AW Oliver, B Vogelstein, B Vogelstein, Bissan Al-Lazikani, C Greenman, C McWhirter, CA Lipinski, CJ Lord, CJ Richardson, D Croft, D Dorjsuren, DM van Pel, DM van Pel, DP Cahill, DW Parsons, E Kuhn, E Pastwa, EB Fauman, EC Friedberg, EK Bancroft, Frances M. G. Pearl, FS Collins, GH Nguyen, GM Kupfer, GP Pfeifer, H Panda, J Bartkova, J Zhang, JL Riffell, JM Daley, JM Murray, JM Paul, JN Weinstein, JP Overington, JW Harper, K Chang, KC Bulusu, KH Khoo, KH Lim, KK Hoe, KL Kanchi, L Galluzzi, L Weiss, Laurence H. Pearl, LB Alexandrov, LB Alexandrov, LJ Barber, LV Liu, M Aggarwal, M Ashburner, M Bastian, M D'Antonio, M Kanehisa, M Tischkowitz, ME Smoot, MN Patel, MS Lindstrom, NC Turner, NG Howlett, NG Jaspers, NJ Curtin, O Espinosa, P Bouwman, P Workman, PA Futreal, PA Janne, PV Hornbeck, Q Liang, R Brough, R Brough, R Buisson, R Mehra, R Nishi, RA Burrell, RE Verdun, S Prakash, SA Forbes, SA Martin, SI Nikolaev, Simon E. Ward, SL Allinson, SP Jackson, T Helleday, TD Halazonetis, TR Mereniuk, V Landre, WG Kaelin Jr., X Jacq, Y Nakazawa, YH Fan, Z Wang   +103 more
core   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [PDF]

, 2019
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes ...
Aguilera López, Andrés, Barroso Ceballos, Sonia Inés, García Rubio, María Luisa, Gómez González, Belén, Herrera Moyano, Emilia, Muñoz Sánchez, Sergio   +5 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

"Erfahrungen der Besten". Die unikale Sammlung Pädagogischer Lesungen der DDR – ein Werkstattbericht

Medienimpulse, 2019
Gegenstand des Beitrags ist die Beschreibung einer rund 9.000 Titel umfassenden Sammlung aller zentral in der DDR prämierten Pädagogischen Lesungen der Jahre 1961 bis 1989. Neben der historischen Spezifität und heterogenen Zusammensetzung des unikalen
Josefine Wähler, Maria-Annabel Hanke
doaj   +1 more source

The Effect of Random Surface Inhomogeneities on Microresonator Spectral Properties: Theory and Modeling at Millimeter Wave Range

, 2008
The influence of random surface inhomogeneities on spectral properties of open microresonators is studied both theoretically and experimentally. To solve the equations governing the dynamics of electromagnetic fields the method of eigen-mode separation ...
A. G. Voronovich, A. N. Kolmogorov, E. M. Ganapolskii, F. G. Bass, J. A. Ogilvy, J. R. Taylor, L. A. Vainshtein, Lord Rayleigh, R. Newton, T. Kato, Yu. V. Tarasov, Z. E. Eremenko   +11 more
core   +1 more source