Results 61 to 70 of about 32,248 (253)
Advanced Science, EarlyView.Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu +14 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller +16 more
wiley +1 more source
Aerial Imagery Redefined: Next-Generation Approach to Object Classification
InformationIdentifying and classifying objects in aerial images are two significant and complex issues in computer vision. The fine-grained classification of objects in overhead images has become widespread in various real-world applications, due to recent ...
Eran Dahan, Itzhak Aviv, Tzvi Diskin
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Cultivating Enduring Changes in Assessment Through a Life Sciences Community of Practice
Biochemistry and Molecular Biology Education, EarlyView.ABSTRACT To provide instructors with personally relevant, discipline‐based training in assessment, the Community for the Assessment of Biochemistry and Molecular Biology Learning (CABL) conducted a series of six participant‐centered workshops between July 2020 and January 2024.
Ludmila Tyler +12 more
wiley +1 more source
Triggered Calcium Lightning Programs Cochlear Development
Exploration, EarlyView.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source
Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome
International Journal of Cancer, EarlyView.ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin +10 more
wiley +1 more source
"Erfahrungen der Besten". Die unikale Sammlung Pädagogischer Lesungen der DDR – ein Werkstattbericht
Medienimpulse, 2019 Gegenstand des Beitrags ist die Beschreibung einer rund 9.000 Titel umfassenden Sammlung aller zentral in der DDR prämierten Pädagogischen Lesungen der Jahre 1961 bis 1989. Neben der historischen Spezifität und heterogenen Zusammensetzung des unikalen
Josefine Wähler, Maria-Annabel Hanke
doaj +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Evidence to guide the treatment for patients with metastatic castration‐resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with tumor harboring HRR alterations, progressed on a prior androgen ...
Lorena Incorvaia +35 more
wiley +1 more source
iMeta, EarlyView.This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang +18 more
wiley +1 more source