Results 51 to 60 of about 208,136 (294)

Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data. [PDF]

open access: yes, 2014
Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year.
Bainbridge, Matthew N   +3 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Ahnung? Erkenntnis? Antizipatorisches in der DDR-Lyrik der Vor-Wende-Zeit

open access: yesInternationale Zeitschrift für Kulturkomparatistik, 2019
The ability of poetry – on the basis of its generic capability to bring together playfulness and awareness, an anticipated future (Ahnung) and the present – has had consequences for the history of German poetry insofar as poetry could function as a ...
Peter Geist
doaj   +1 more source

The statistical mechanics of combinatorial optimization problems with site disorder [PDF]

open access: yes, 2005
We study the statistical mechanics of a class of problems whose phase space is the set of permutations of an ensemble of quenched random positions. Specific examples analyzed are the finite temperature traveling salesman problem on several different ...
A. Barvinok   +9 more
core   +4 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Experimental determination and practical application of the four-pole parameters of structure-borne sound isolators

open access: yesArchives of Acoustics, 2016
Theoretical fundamentals are derived for measuring the four-pole para-meters of vibration isolators at real loads. Since the dynamic properties of rubber springs depend on the initial load, the vibration force and velocity are measured on the isolator ...
G. MELTZER, R. MELZIG-THIEL
doaj  

Representation of Integral Dispersion Relations by Local Forms

open access: yes, 2008
The representation of the usual integral dispersion relations (IDR) of scattering theory through series of derivatives of the amplitudes is discussed, extended, simplified, and confirmed as mathematical identities.
Ferreira, Erasmo, Sesma, Javier
core   +1 more source

Opportunities of Semiconducting Oxide Nanostructures as Advanced Luminescent Materials in Photonics

open access: yesAdvanced Materials, EarlyView.
The review discusses the challenges of wide and ultrawide bandgap semiconducting oxides as a suitable material platform for photonics. They offer great versatility in terms of tuning microstructure, native defects, doping, anisotropy, and micro‐ and nano‐structuring. The review focuses on their light emission, light‐confinement in optical cavities, and
Ana Cremades   +7 more
wiley   +1 more source

Neuere heterocyclische Zwischenprodukte für die Azokupplung durch Cyclisierung von Nitrilen

open access: yesCHIMIA, 1980
Two types of syntheses of heteroaromatic amines by cyclization of nitriles are described. It is dealt with the cyclization of nitriles by elemental sulphur yielding thiophenes and thiazoles and with some reactions of the resulting 2-amino-thiophene-3 ...
Karl Gewald
doaj   +1 more source

Induction of Stress Granule Assembly is Essential for the Orchestration of DNA Damage Response [PDF]

open access: yes, 2008
DNA damage provokes several responses including DNA repair, cell cycle regulation and apoptosis that collectively represent the DNA damage response (DDR).
Nicole S. Verkaik, Stephan Persengiev
core   +1 more source

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