Results 51 to 60 of about 32,248 (253)

Neuere heterocyclische Zwischenprodukte für die Azokupplung durch Cyclisierung von Nitrilen

CHIMIA, 1980
Two types of syntheses of heteroaromatic amines by cyclization of nitriles are described. It is dealt with the cyclization of nitriles by elemental sulphur yielding thiophenes and thiazoles and with some reactions of the resulting 2-amino-thiophene-3 ...
Karl Gewald
doaj   +1 more source

REPENSER LE PROCESSUS DDR EN RÉPUBLIQUE DÉMOCRATIQUE DU CONGO A L’HEURE DE L’ALTERNANCE POLITIQUE [PDF]

Cahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable, 2023
Le présent article revisite le processus DDR - Désarmement, Démobilisation et Réinsertion-, en République Démocratique du Congo, au moment où, dans le contexte actuel de l’alternance politique, intervenue à la suite des dernières élections de 2018, il ...
Nelson PALUKU SYAYIPUMA
doaj  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Implementing DDR in Settings of Ongoing Conflict: The Organization and Fragmentation of Armed Groups in the Democratic Republic of Congo (DRC)

Stability : International Journal of Security and Development, 2016
Although it is common for armed groups to splinter (or “fragment”) during contexts of multi-party civil war, current guidance on Disarmament, Demobilization, and Reintegration (DDR) does not address the challenges that arise when recalcitrant fighters ...
Joanne Richards
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Las Farianas: Reintegration of former female FARC fighters as a driver for peace in Colombia

Cuadernos de Economía, 2019
The 2016 peace agreement includes comprehensive prescriptions for the so-called “reincorporation” of former combatants into the social, economic and political life of Colombia.
Laura Camila Barrios Sabogal, Solveig Richter   +1 more
doaj   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Enabling cyber-physical demand response in smart grids via conjoint communication and controller design

IET Cyber-Physical Systems, 2019
This study proposes a novel user-centric cyber-physical framework to achieve distributed demand response (DDR) in a distribution system where local schedulers (LS) present at individual buses program both local and non-local loads to reduce the maximum ...
Swaroop Ranjan Mishra, Meher Preetam Korukonda, Laxmidhar Behera, Anupam Shukla   +3 more
doaj   +1 more source