Results 71 to 80 of about 208,136 (294)
From conflict to ownership: Participatory approaches to the re-integration of ex-combatants in Sierra Leone [PDF]
, 2011 The demobilisation and re-integration of ex-combatants has become an important element in peace-building. The need for a more holistic, integrated approach, in which there is greater local ownership of the process, has long been recognised.
Kilroy, Walt
core +2 more sources
Advanced Science, EarlyView.Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang +10 more
wiley +1 more source
A Lagrangian Neighbourhood Theorem for shifted symplectic derived schemes [PDF]
, 2015 Pantev, Toen, Vaqui\'e and Vezzosi arXiv:1111.3209 defined $k$-shifted symplectic derived schemes and stacks ${\bf X}$ for $k\in\mathbb Z$, and Lagrangians ${\bf f}:{\bf L}\to{\bf X}$ in them.
Joyce, Dominic, Safronov, Pavel
core +3 more sources
Advanced Science, EarlyView.High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu +10 more
wiley +1 more source
Advanced Science, EarlyView.TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng +9 more
wiley +1 more source
Aerial Imagery Redefined: Next-Generation Approach to Object Classification
InformationIdentifying and classifying objects in aerial images are two significant and complex issues in computer vision. The fine-grained classification of objects in overhead images has become widespread in various real-world applications, due to recent ...
Eran Dahan, Itzhak Aviv, Tzvi Diskin
doaj +1 more source
Investigating the Dirac operator evaluation with FPGAs [PDF]
, 2019 In recent years the computational capacity of single Field Programmable Gate Arrays (FPGA) devices as well as their versatility has increased significantly.
Korcyl, G., Korcyl, P.
core +2 more sources
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Advanced Science, EarlyView.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Las Farianas: Reintegration of former female FARC fighters as a driver for peace in Colombia
Cuadernos de Economía, 2019 The 2016 peace agreement includes comprehensive prescriptions for the so-called “reincorporation” of former combatants into the social, economic and political life of Colombia.
Laura Camila Barrios Sabogal +1 more
doaj +1 more source