Results 131 to 140 of about 32,248 (253)

Breaking the Balance: Baseline Oxidative Stress and DNA Repair Capacity in Multiple Myeloma Therapy. [PDF]

Cancers (Basel)
Malamos P, Deligianni E, Voutetakis K, Koutoulogenis K, Papadodima O, Terpos E, Souliotis VL.   +6 more
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

CDK7 as a Potential Exploratory Biomarker for Distinguishing Acute Myocardial Infarction Subtypes via DDR Pathways: Evidence From a Bangladeshi Cohort. [PDF]

Clin Cardiol
Ripon RH, Zahin H, Noman AA, Saba AA, Sayem M, Nabi AHMN, Yasmin T.   +6 more
europepmc   +1 more source

DUSP12 Regulates NAT10‐Mediated RNA Acetylation to Modulate DNA Repair and Therapeutic Response in Hepatocellular Carcinoma

MedComm, Volume 7, Issue 9, September 2026.
In hepatocellular carcinoma (HCC) cells exposed to doxorubicin, DUSP12 depletion maintains NAT10 phosphorylation, reducing its acetyltransferase activity, which leads to reduced ac4C RNA acetylation, DNA damage response, and DNA break repair, with consequent tumor sensitization.
Viktor Kalbermatter Boell, Diana Reis Della Corte Guimarães Pacheco, Yuli Thamires Magalhães, Laura Lima Turani, Isabeli Yumi Araújo Osawa, Nicolas Carlos Hoch, Fábio Luís Forti   +6 more
wiley   +1 more source

Genomic characterization of DNA damage response pathway mutations reveals their adverse impact on EGFR-TKI efficacy in non-small cell lung cancer. [PDF]

Respir Res
Yang L, Cheng J, Guo X, Xiao H, Kuang X, Yang Y, Zhang L, Zhang Q, Wang D, Xu Y, Li M.   +10 more
europepmc   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Merkel Cell Polyomavirus and DNA Damage Response (DDR): Transcriptional Analysis of DDR Pathways in the Context of Merkel Cell Carcinoma. [PDF]

Cancers (Basel)
Messina S, Mallardo D, Ferlosio A, Festino L, Trojaniello C, Di Trolio R, Ciotti M, Ascierto PA, Pietropaolo V, Passerini S.   +9 more
europepmc   +1 more source

Dedicated Endoscopy for Barrett's Oesophagus With Higher Dysplasia Yield May Reduce Seattle Protocol Biopsies: Results From UK Multicentre Study

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Dedicated service for Barrett's oesophagus (BO) surveillance may be more effective than conventional service, according to some single centre studies. Objective To determine whether the surveillance of BO through a dedicated service can improve key performance indicators (KPIs), and dysplasia detection rate (DDR) compared with ...
Champika Gamakaranage, James Britton, Elizabeth Ratcliffe, Neeraj Prasad, Richard Keld, Mark Murgatroyd, Shanmugasundaram Balakrishnan, Nazar Aslam, Vinay Sehgal, Jenni Marsh, Daniel Plant, Matthew Johnston, Stefanos Kateroglou, Jake Baker, Hannah Morgan, Claudia Cipriano, Anjan Dhar, Shaheen Hamdy, John McLaughlin, Yeng Ang, on behalf ofDEBO group   +20 more
wiley   +1 more source

Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology. [PDF]

Neoplasia
Zhu H, Shao J, Wang Y, Gu C, Liu J.
europepmc   +1 more source

Long-Term PET-Nanoplastic Exposure Alters DNA Damage Response Capacity in BEAS-2B Human Bronchial Epithelial Cells. [PDF]

Int J Mol Sci
Morataya-Reyes M, Villacorta A, Egea R, Martín-Pérez J, Gutiérrez-García J, Pastor S, Marcos R, Hernández A.   +7 more
europepmc   +1 more source