Results 31 to 40 of about 190,243 (246)

“Perché proprio Napoleone?”: Neue Lebensansichten eines Katers come prima riscrittura femminista nell’opera di Christa Wolf

Lea, 2023
Il racconto di Christa Wolf Neue Lebensansichten eines Katers viene solitamente interpretato come una satira socio-scientifica rivolta contro le aspirazioni tecnocratiche della DDR e all'interno della quale le donne non rivestono che un ruolo marginale ...
Carmen Mitidieri
doaj   +1 more source

Therapeutic opportunities within the DNA damage response [PDF]

, 2015
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the cell, and its disruption is one of the hallmarks of cancer.
A Chatr-Aryamontri, A Franceschini, A Franchitto, A Gaulton, AA Larrea, AC Antoniou, AE Tomkinson, AJ Bardin, AK Rustgi, AL Chambers, AL Marston, Amanda C. Schierz, AP Eker, AW Oliver, B Vogelstein, B Vogelstein, Bissan Al-Lazikani, C Greenman, C McWhirter, CA Lipinski, CJ Lord, CJ Richardson, D Croft, D Dorjsuren, DM van Pel, DM van Pel, DP Cahill, DW Parsons, E Kuhn, E Pastwa, EB Fauman, EC Friedberg, EK Bancroft, Frances M. G. Pearl, FS Collins, GH Nguyen, GM Kupfer, GP Pfeifer, H Panda, J Bartkova, J Zhang, JL Riffell, JM Daley, JM Murray, JM Paul, JN Weinstein, JP Overington, JW Harper, K Chang, KC Bulusu, KH Khoo, KH Lim, KK Hoe, KL Kanchi, L Galluzzi, L Weiss, Laurence H. Pearl, LB Alexandrov, LB Alexandrov, LJ Barber, LV Liu, M Aggarwal, M Ashburner, M Bastian, M D'Antonio, M Kanehisa, M Tischkowitz, ME Smoot, MN Patel, MS Lindstrom, NC Turner, NG Howlett, NG Jaspers, NJ Curtin, O Espinosa, P Bouwman, P Workman, PA Futreal, PA Janne, PV Hornbeck, Q Liang, R Brough, R Brough, R Buisson, R Mehra, R Nishi, RA Burrell, RE Verdun, S Prakash, SA Forbes, SA Martin, SI Nikolaev, Simon E. Ward, SL Allinson, SP Jackson, T Helleday, TD Halazonetis, TR Mereniuk, V Landre, WG Kaelin Jr., X Jacq, Y Nakazawa, YH Fan, Z Wang   +103 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dependence of the Sheet Resistivity and Current Noise Behaviour of the Grain Size and Volume Fraction of Conducting Material in Thick-Film Resistors Experiments

Active and Passive Electronic Components, 1988
Experimental results concerning the dependence of the sheet resistivity and the noise coefficient on the grain size and the volume fraction, respectively, of the metallic-like component in Bi2Ru2O7-based thick-film resistors are presented.
F. Müller, M. Wolf
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Barreras psicosociales para la vinculación laboral de excombatientes

Revista Kavilando, 2021
En el marco de la firma del acuerdo de paz entre las FARC-EP y el gobierno colombiano, surge la inquietud de cómo se están dando los procesos de inclusión laboral de los desmovilizados y qué papel juegan las Barreras psicosociales para la paz, por lo que
Glenda C Soto Chima, Manuela Trujillo Valencia, Juan David Villa Gómez   +2 more
doaj  

REPENSER LE PROCESSUS DDR EN RÉPUBLIQUE DÉMOCRATIQUE DU CONGO A L’HEURE DE L’ALTERNANCE POLITIQUE [PDF]

Cahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable, 2023
Le présent article revisite le processus DDR - Désarmement, Démobilisation et Réinsertion-, en République Démocratique du Congo, au moment où, dans le contexte actuel de l’alternance politique, intervenue à la suite des dernières élections de 2018, il ...
Nelson PALUKU SYAYIPUMA
doaj  

Disarmament, Demobilization, and Reintegration: The co-evolution of concepts, practices, and understanding [PDF]

, 2009
Programs for the Disarmament, Demobilization, and Reintegration (DDR) of ex-combatants have become more common as an element in the peacebuilder’s toolkit.
Kilroy, Walt
core  

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source