The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy [PDF]
, 2019 BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.
Ceppa, Eugene P. +16 more
core +1 more source
Programming of stress-related behavioral and neuroendocrine functions during early life [PDF]
, 2013 Tese de doutoramento em MedicinaThroughout ontogeny the mammalian brain shows windows of time during which there is an increased sensitivity towards the programming effects of external and endogenous signals.
Patchev, Alexandre Vladimirov
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Studies on the impact of amine-containing compounds on lysosomes [PDF]
, 2011 Lysosomes accumulate weakly basic amine-containing drugs (i.e., lysosomotropic amines) through an ion trapping-type mechanism and are capable of disrupting lysosomal structure and function.
Funk, Ryan S.
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Lihaskudoksen NAD+-puutos ja Serpina3n molekyylibiologisina tekijöinä hiirten syöpäkakeksiassa – myostatiinin ja aktiviinien estäjien vaikutus [PDF]
, 2022 Syöpäkakeksia on patofysiologialtaan vielä suurelta osin tuntematon, monitekijäinen aineenvaihdunnallinen sairaus, jossa paino ja lihaskudoksen määrä laskevat.
Ballarò, Riccardo +12 more
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Multi-minicore Disease Revisited. [PDF]
, 2015 Multi-minicore disease (MmD) is an infrequent congenital myopathy, defined by structural changes in optic and electron microscopy, namely, multiple small areas lacking oxidative enzyme activity and focal disorganization of contractile proteins involving ...
Martins Filho, José +3 more
core
Chronic Lung Disease in Cutis Laxa [PDF]
, 2011 BACKGROUND: Cutis laxa (CL) is a group of disorders characterized by loose, inelastic, and redundant skin. The different types of CL are distinguished by clinical features, inheritance, and molecular findings.
Westman, Rachel E
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Defining the Pulmonary Disease and Disability from Lung Dysfunction in Cutis Laxa [PDF]
, 2012 Cutis laxa is a heterogeneous group of disorders characterized by loose, lax, and inelastic skin. Other complications include lung, cardiovascular, musculoskeletal, gastrointestinal, and genitourinary disease.
Mac Neal, Meghan Kelly
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First report of a short in-frame biallelic deletion removing part of the EGF-like domain calcium-binding motif in LTBP4 and causing autosomal recessive cutis laxa type 1C. [PDF]
Am J Med Genet A, 2022 Ravel JM +8 more
europepmc +1 more source
Two novel mutations in ALDH18A1 and SPG11 gene found by whole-exome sequencing in spastic paraplegia disease patients in Iran. [PDF]
Genomics Inform, 2022 Komachali SR, Siahpoosh Z, Salehi M.
europepmc +1 more source