Results 191 to 200 of about 2,481,224 (301)

EASIX Score as an Independent Prognostic Marker in De Novo Metastatic Pancreatic Cancer. [PDF]

Medicina (Kaunas)
Çıtakkul İ, Temi YB, Aytin Z, Baydar E, Kefeli U, Çabuk D, Uygun K.   +6 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Prevalence and genetics of "de novo" MEN2 syndromes.

J Clin Endocrinol Metab
Casalini R, Romei C, Bottici V, Cappagli V, Tascini V, Matrone A, Prete A, Ciampi R, Ramone T, Elisei R.   +9 more
europepmc   +1 more source

De novo protein-ligand design including protein flexibility and conformational adaptation. [PDF]

Bioinformatics
Agamia J, Zacharias M.
europepmc   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

De novo origin of numerous microproteins in enterobacteria. [PDF]

Nucleic Acids Res
Fesenko I, Shabalina SA, Storz G, Koonin EV.   +3 more
europepmc   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

De Novo Malignancies after Liver Transplantation: A Multicenter Cohort Study of Incidence, Timing, and Outcomes. [PDF]

Turk J Gastroenterol
Danış N, Döngelli H, Ünek T, Bacakoğlu A, Turan İ, Karasu AZ, Günşar F, Işık E, Harputluoglu MM, Sağlam K, Yılmaz S, Çavuş B, Kaymakoglu S, Adanır H, Dinçer D, Arı D, Akdogan Kayhan M, Turan Gokce D, Kabacam G, Karademir S, Kıyıcı M, Cesur S, Gokcan H, Melekoglu Ellik Z, İdilman R, Dayangaç M, Balaban Y, Doğrul AB, Dinçer HA, Adalı G, Dilber F, Gulsen MT, Sezgin O, Harput ZN, Akyıldız M, Moral K, Egeli T, Ağalar C, Özbilgin M, Akarsu M.   +39 more
europepmc   +1 more source

Novos Pobres. O Que Há de Novo?

, 2019
O texto lança mão dos conceitos de 'fundo público', elaborado por Francisco de Oliveira em "O surgimento do anti-valor"/1988 e de 'sociedade do bem estar', elaborado por Rosanvallon, em "la crise de l'Etat-Providence" / 1981, para discutir a emergência da categoria social dos 'novos pobres' enquanto fenômeno contemporâneo resultante do desemprego ...
openaire   +1 more source