Results 201 to 210 of about 563,940 (260)

Genetic Insights Into Retinitis Pigmentosa: A De Novo <i>RPGR</i> Mutation in an Iranian-Azeri Family. [PDF]

Case Rep Ophthalmol Med
Ghezelbash N, Bonyadi M, Bonyadi MHJ.
europepmc   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Identification of a Novel De Novo HECW2 Gene Pathogenic Variant in a Fetus With Cardiac Abnormalities. [PDF]

Prenat Diagn
Nimchenko K, Bessieres B, Chalouhi GE, Pop A, Castaigne V, Stos B, Beaujard MP, Roy D, Laux D, Attie-Bitach T.   +9 more
europepmc   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

Engineering short-sequence elements for condensate-like assemblies by de novo design. [PDF]

Synth Syst Biotechnol
Zhang D, Zhang B, Zheng C, Sun W, Niu H, Zhu C, Chen Y, Liu D, Ying H.   +8 more
europepmc   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

De novo haplotype-resolved genome assembly of the endemic kiwifruit Actinidia hubeiensis. [PDF]

Sci Data
Wang Z, Hu G, Zhang Y, Gao L, Luo X, Xiao Q, Ye L, Huang Q, Xiao T, Zhang L, Jiang Q.   +10 more
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Breaking the membrane heredity paradox through de novo protocell formation. [PDF]

Nat Commun
Khanal S, Fracassi A, Harjung A, Burkart MD, Devaraj NK.   +4 more
europepmc   +1 more source

Cortical and subcortical morphological alterations in <i>de novo GBA</i>-related Parkinson's disease. [PDF]

Front Aging Neurosci
Ren J, Xing Y, Zhou H, Hong X, Huang X, Liu W.   +5 more
europepmc   +1 more source