Results 231 to 240 of about 2,481,224 (301)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

The first dataset of de novo assembled transcriptome of Aspidiotus destructor Signoret (Hemiptera: Diaspididae). [PDF]

Data Brief
Geronca J, Egana JMC, Cleofe MAS, Bautista MAM.   +3 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Identification of de novo variants from parent-proband duos via long-read sequencing. [PDF]

Am J Hum Genet
Boukas L, Délot EC, Pitsava G, Lambert C, Fanslow C, Baybayan P, Belhadj S, Losic B, Harting J, Bluske K, LoTempio J, Al-Kouatly HB, Karam R, Rowell WJ, Xiao C, Vilain E, Berger SI.   +16 more
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Stimuli-triggered formation of <i>de novo</i>-designed protein biomaterials. [PDF]

Cell Biomater
Gregorio NE, Li Z, Hoye JW, Baker D, DeForest CA.   +4 more
europepmc   +1 more source

WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement

Advanced Science, EarlyView.
This review synthesizes emerging insights into WUSCHEL (WUS) as a central regulator of plant stem cell fate beyond Arabidopsis, highlighting its roles in regeneration, somatic embryogenesis (SE), and stress adaptation across crops. It explores how WUS‐centered regulatory networks, genome editing, and AI‐guided strategies can be leveraged for precise ...
Zishan Ahmad, Muthusamy Ramakrishnan, Rajeev K. Varshney, Anwar Shahzad, Shamsur Rehman, Bijaya Pant, Qiang Wei   +6 more
wiley   +1 more source

De novo heterozygous variants of the RSF1 gene are responsible for a syndromic neurodevelopmental disorder. [PDF]

Eur J Hum Genet
Jost C, Busa T, Wegner D, Shinawi M, Schaefer E, Piton A, Schluth-Bolard C, Charles P, Keren B, Mayerhanser K, Brunet T, Schatz U, Neil JE, Walsh CA, Sisco K, J Paul A, Undiagnosed Diseases Network, Lee C, Dykzeul N, Bonner D, Bernstein JA, Sutcliffe E, Wentzensen IM, Froehlich C, Liebler K, Galvin Parton P, Weiss-Burns J, Sagnol C, Delanne J, Racine C, Thauvin-Robinet C, Safraou H, Tran Mau-Them F, Duffourd Y, Bruel AL, Faivre L.   +35 more
europepmc   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Peri-Ictal MRI Abnormalities and Risk of Unprovoked Seizures After De Novo Status Epilepticus. [PDF]

Neurology
Orav K, Bosque-Varela P, Lauth W, Machegger L, Jannone-Pedro N, Leitinger M, Pfaff J, Trinka E, Kuchukhidze G.   +8 more
europepmc   +1 more source