Results 121 to 130 of about 32,587 (229)

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p

Nature Communications
DEAD-box RNA-dependent ATPases are ubiquitous in all domains of life where they bind and remodel RNA and RNA-protein complexes. DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement ...
Eric M. Patrick, Rajeev Yadav, Kasun Senanayake, Kyle Cotter, Andrea A. Putnam, Eckhard Jankowsky, Matthew J. Comstock   +6 more
doaj   +1 more source

Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.

, 2019
Translation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown.
Beissel , C., Hampe , I., Karki, P., Krebber, H., Neumann, B., Uhse, S.   +5 more
core   +1 more source

Vernalization regulatory network identifies potential novel functions for genes in the HvVRN2 locus

New Phytologist, EarlyView.
Summary Flowering is controlled by environmental and genetic factors. Vernalization requirement in barley (Hordeum vulgare L.) is determined by the allele in HvVRN1 and the presence of locus HvVRN2, which consists of two zinc‐finger and CONSTANS‐like domains (ZCCT) genes: HvVRN2a and HvVRN2b.
Francesc Montardit‐Tarda, Irene Puyó, Bruno Contreras‐Moreira, Ildikó Karsai, Philippa Borrill, Ana M. Casas, Ernesto Igartua   +6 more
wiley   +1 more source

DEAD box RNA helicases crucial regulators of gene expression and oncogenesis

Frontiers in Bioscience, 2016
DEAD box protein family of RNA helicases are vital players of RNA metabolism, and constitute the largest family of RNA helicases. Members of this family share nine conserved motifs including an Asp-Glu-Ala-Asp motif, giving this family its characteristic name as DEAD box RNA helicases.
Moumita, Sarkar, Mrinal Kanti, Ghosh
openaire   +2 more sources

Methionine Synthase Positively Regulates Plant Defence to Both RNA and DNA Viruses and Is Useful for Developing Broad‐Spectrum Antiviral Resistance in Crops

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses frequently cause severe economic losses in worldwide crop production. Developing broad‐spectrum resistance is the most efficient approach for controlling plant viral diseases. In this work, we found that the 17K protein of barley yellow dwarf viruses (BYDVs), which has multiple functions in viral pathogenesis including acting as ...
Zhaohui Wang, Kunpu Zhang, Chi Zhang, Jin Yang, Bei Li, Lina Wang, Zhenghao Shi, Rui Guo, Shuai Zhang, Kaiqi Gao, Jianing Li, Xiaohuan Jin, Xiang Ji, Huihui Bi, Liyuan You, Huaibing Jin, Daowen Wang   +16 more
wiley   +1 more source

The DEAD-Box RNA Helicases of Bacillus subtilis as a Model to Evaluate Genetic Compensation Among Duplicate Genes

Frontiers in Microbiology, 2018
The presence of duplicated genes in organisms is well documented. There is increasing interest in understanding how these genes subfunctionalize and whether functional overlap can explain the fact that some of these genes are dispensable.
José Antonio González-Gutiérrez, Diana Fabiola Díaz-Jiménez, Itzel Vargas-Pérez, Gabriel Guillén-Solís, Jörg Stülke, Gabriela Olmedo-Álvarez   +5 more
doaj   +1 more source

Linking the DEAD‐box RNA helicase Ded1p to cellular RNA targets

The FASEB Journal, 2012
RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of eukaryotic RNA metabolism. In vitro, helicases bind or remodel RNA or RNA‐protein complexes in an ATP‐dependent fashion, but how these activities are used in the cellular function of these enzymes has remained elusive. This is mainly because RNA targets and
openaire   +1 more source